Reprint

Selected Papers from the 3rd International Symposium on Life Science

Edited by
July 2020
258 pages
  • ISBN978-3-03928-728-4 (Hardback)
  • ISBN978-3-03928-729-1 (PDF)

This book is a reprint of the Special Issue Selected Papers from the 3rd International Symposium on Life Science that was published in

Biology & Life Sciences
Chemistry & Materials Science
Medicine & Pharmacology
Summary

This book contains information for specialists in various fields of science. From the point of view of pharmacology, data are reported regarding the effect of echinochrome A and related metabolites from sea urchins on the survival and functional properties of stem cells, which can facilitate ex vivo application of this compound in medicine. For scientists who isolate and establish structures of marine natural compounds, an article devoted to the proof of the microbial origin of a typical metabolite earlier found exclusively from marine invertebrates, 6-epi-monanchorin, may also be of interest. A range of new marine metabolites was discovered from the both marine invertebrates and marine microorganisms, particularly in marine isolates of fungi. Some marine natural products could be applied to treat such diseases as Parkinson’s disease, ischemic stroke, viral infections, and so on. Magnificamide, a new peptide from sea anemones, inhibits porcine and human saliva amylases, showing its probable antidiabetic properties. Application of the genomic approach was discussed in studies on various marine bacteria, producing marine enzymes with unusual specificity. The lectins capable of recognizing glycoforms of different substrates demonstrate the possibility to be used to elaborate new medical diagnostics.

Format
  • Hardback
License
© 2020 by the authors; CC BY-NC-ND license
Keywords
carrageenan; algae; echinochrome; reactive oxygen species; cytokines; HT-29; neuroprotective activity; Parkinson’s disease; ROS; DPPH-scavenging activity; 6-OHDA; paraquat; marine fungal metabolites; secondary metabolites; oxygenated steroids; marine sponge; Inflatella; NMR; ROS; Parkinson’s disease; structure-activity relationship; galactose-specific lectin; Crenomytilus grayanus; carbohydrate-binding site; molecular docking; site-specific mutagenesis; carbohydrate-binding activity; echinochrome A; composition of antioxidants; antioxidant activity; antiviral activity; Spinochrome D; doxorubicin; cardioprotective effect; guanidine alkaloids; 6-epi-monanchorin; HRESI MS; 1H NMR spectra; marine bacteria; Vibrio sp.; polychaete; Chaetopterus variopedatus; 16S rRNA gene analysis; phylogenetic reconstruction; cardiac progenitor cells; histochrome; echinochrome A; oxidative stress; cell therapy; Flu; alga; sulphated polysaccharides; alginates; lectins; polyphenols; anti-viral activity; gliotoxin; DAPK1; TAp63; autophagy; drug resistance; ovarian cancer; marine sponge; Halichondria vansoesti; trisulfated steroids; topsentiasterol sulfates; halistanol sulfates; anticancer activity; PSA expression; glucose uptake; echinochrome A; brain ischemic stroke; cell survival; hematopoietic stem and progenitor cells; CD34+ cells; ex vivo expansion; Lyn; Src; p110δ; ROS; Cnidaria; sea anemones; venom; amylase inhibitors; defensin; diabetes; echinochrome A; marine drugs; inflammatory bowel disease; regulatory T cells; macrophages; recombinant alkaline phosphatase; bimetal-dependent phosphodiesterase; marine bacterium; Cobetia amphilecti; PhoD; marine flavobacteria; Zobellia; comparative genomics; carbohydrate-active enzymes; n/a