*4.1. Materials*

21-amino-*N*-(9-fluorenylmethoxycarbonyl)-4,7,10,13,16,19-hexaoxaheneicosanoic acid (Fmoc-*N*-amido-dPEG6 acid), 39-amino-*N*-(9-fluorenylmethoxycarbonyl)-4, 7, 10, 13, 16, 19, 22, 25, 28, 31, 34, 37-dodecaoxanonatriacontanoic acid (Fmoc-*N*-amido-dPEG12 acid), and O-[*N*- (9-fluorenylmethoxycarbonyl)-2-aminoethyl]-O'-(2-carboxyethyl) undecaethyleneglycol (Fmoc-*N*amido-dPEG24 acid) were purchased from Quanta BioDesign Ltd. (Plain City, OH, USA). 2-chlorotrityl chloride resin, *N*,*N*'-diisopropylethylamine (DIPEA), all the L-Fmoc amino acids, 1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate (HBTU), 1-hydroxybenzotriazole (HOBT), and piperidine were purchased from Watanabe Chemical Industries Ltd. (Hiroshima, Japan). *N*,*N*'-dimethylformamide (DMF), isopropanol, methanol, diethyl ether, hexafluoroisopropanol (HFIP), dichloromethane (CH2Cl2), trifluoroacetic acid (TFA), and granulocyte-macrophage colony-stimulating factor (GM-CSF) were purchased from Wako Pure Chemical Industries, Ltd. (Osaka, Japan). Eagle's minimal essential medium (EMEM), penicillinstreptomycin, and lipopolysaccharides from *Escherichia coli* O55:B5 were purchased from Sigma-Aldrich (St. Louis, MO, USA). *N*6-[(3 ,6 -Dihydroxy-3-oxospiro[isobenzofuran-1(*3H*),9 -[*9H*]xanthen]-5-yl) carbonyl]-*N*2-[(*9H*-fluoren-9-ylmethoxy)carbonyl]-L-lysine (Fmoc-Lys(5-FAM)-OH) was purchased from AAT Bioquest (Sunnyvale, CA, USA). LysoTracker Red DND-99, and Hoechst 33342, trihydrochloride, trihydrate were purchased from Thermo Fisher Scientific (Waltham, MA, USA). Fetal bovine serum (FBS) was purchased from Biowest (Nuaillé, France). Purified anti-mouse CD16/CD32 (2.4G2) and anti-mouse CD86 (B7-2) PE were purchased from Tonbo Biosciences (San Diego, CA, USA). The ELISA Kit for mouse TNF-alpha and IL-6 were purchased from R&D Systems (Minneapolis, MN, USA).

#### *4.2. Experimental Methods*
