**Phytic Acid and Mineral Biofortification Strategies: From Plant Science to Breeding and Biotechnological Approaches**

### **Eleonora Cominelli 1,\*, Roberto Pilu 2 and Francesca Sparvoli 1**


Received: 23 March 2020; Accepted: 24 April 2020; Published: 26 April 2020

**Abstract:** Mineral deficiencies, particularly for iron and zinc, a ffect over two billion people worldwide, mainly in developing countries where diets are based on the consumption of staple crops. Mineral biofortification includes di fferent approaches aimed to increase mineral concentration and to improve mineral bioavailability in the edible parts of plants, particularly the seeds. A multidisciplinary approach, including agronomic, genetic, physiological, and molecular expertise, is necessary to obtain detailed knowledge of the complex homeostatic mechanisms that tightly regulate seed mineral concentrations and the molecules and mechanisms that determine mineral bioavailability, necessary to reach the biofortification objectives. To increase bioavailability, one strategy is to decrease seed content of phytic acid, a highly electronegative molecule present in the cell that chelates positively charged metal ions, many of which are important for human nutrition. All the contributions of the current Special Issue aim at describing new results, reviewing the literature, and also commenting on some of the economic and sociological aspects concerning biofortification research. A number of contributions are related to the study of mineral transport, seed accumulation, and approaches to increase seed micronutrient concentration. The remaining ones are mainly focused on the study of *low phytic acid* mutants.

**Keywords:** biofortification; *low phytic acid* (*lpa*) mutants; metal transporter; mineral deficiencies; phytic acid
