*4.9. Statistical Analysis*

Statistical comparison was performed using Student's *t*-test. Differences were considered statistically significant when *p* < 0.05. For lipid analysis, 6 independent experiments for cells and EVs were carried out.

**Supplementary Materials:** Supplementary materials can be found at http://www.mdpi.com/1422-0067/19/11/ 3515/s1.

**Author Contributions:** S.B., L.U. and K.S. designed and carried out the experiments. E.C. carried out the experiments. D.C. and N.M. carried out lipid analysis and evaluated data. C.E., S.B. and L.U. analysed results and wrote the paper. All authors reviewed and critically revised the paper.

**Funding:** This work funded by Fondazione Cassa di Risparmio di Perugia Grant No. 2016.0050.021 to Carla Emiliani and by University of Perugia Grant FONDO D'ATENEO PER LA RICERCA DI BASE 2015.

**Conflicts of Interest:** The authors declare no conflicts of interest.
