*3.8. Statistical Analysis*

Statistical analyses were conducted using Prism software v6.0 (GraphPad Software, La Jolla, CA, USA). Statistical significance was determined by the two-tailed unpaired Student's *t*-test. A *p*-value < 0.05 was considered to be statistically significant. The statistical parameters (i.e., exact value of *n*, *p*-values) have been noted in the figures and figure legends. Unless otherwise indicated, all data represent the mean ± standard error of the mean (SEM) from at least three independent experiments.
