*3.4. General Synthetic Procedure for Lipoamino Acid Methyl Ester Synthesis*

To a mixture of the fatty acid (100 mg), amino acid methyl ester (1 equiv.) and HATU (1.5 equiv.) was added Dimethylformamide (DMF) (5 mL) followed by *N*,*N*-Diisopropylethylamine (DIEA) (3 equiv.) under a N2 atmosphere. The reaction mixture was stirred at room temperature (RT) overnight. A saturated solution of ammonium chloride (NH4Cl) was added and the reaction mixture was extracted with *tert*-butylmethylether (3 times). The combined organic phases were dried with Na2SO4 and concentrated in vacuo. The crude mixture was purified by flash chromatography on silica gel to provide compounds **4**–**21**. Analytical data including optical rotations are reported in the Supplementary Materials.

## *3.5. General Synthetic Procedure for Lipoamino Acid Synthesis*

To a solution of the lipoamino acid methyl ester (50 mg) in methanol (5 mL) and water (0.5 mL) was added LiOH.H2O (5 equiv.). The reaction mixture was stirred at RT for 4 h and then aqueous HCl (1 M) was added to adjust the pH to 2–3. The resulting mixture was extracted twice with ethyl acetate, dried with Na2SO4, and concentrated in vacuo to provide the pure compounds **22**–**39**. Analytical data, including optical rotations, are reported in the Supplementary Materials.
