*4.11. Cytotoxicity Evaluation*

The crude extract for each strain was tested to determine its cytotoxicity using the MRC-5 (ATCC CCL-171) normal human lung fibroblast cells (LGC standards, Molsheim, France). MRC-5 cells were seeded into 96-well microplates at 2000 cells per well. The assay was conducted according to the procedure described by Tempête et al. [30]. After 24 h in wells, solubilized extracts in DMSO are deposited in triplicate as well as the solvent and docetaxel (Taxotère) controls. Cell viability is evaluated in comparison with untreated control cultures after 3 days. Extracts are tested at the concentration of 10 μg/mL.

#### **Supplementary Materials:** Supplementary materials can be found at http://www.mdpi.com/1422-0067/20/8/2006/ s1.

**Author Contributions:** M.B. performed the experiments, analysed the data and wrote the article. N.E., L.P. contributed to analysis tools and analysed the data. J.-L.W., D.S., D.T. and V.E. designed the study. All authors read and approved the manuscript.

**Funding:** This work has benefited from a joint Agence Nationale de la Recherche - Swiss National Science Foundation (ANR-SNF) grant (SECIL, ref ANR-15-CE21-0016 and SNF N◦ 310030E-164289) and from an "Investissement d'Avenir" grant (CEBA, ref ANR-10-LABX-0025) managed by the ANR.

**Conflicts of Interest:** The authors declare no conflict of interest.
