*4.7. Data Analysis*

Statistical analysis was performed using Prism (GraphPad Software, San Diego, USA). Data was tested for normality using a D'Agostino-Pearson omnibus normality test. Parametric data is reported as mean ± standard error of mean. Non-parametric data is reported as median (IQR). Unpaired and parametric samples were analyzed using a Student's t-test. Unpaired and non-parametric samples were analyzed using a Mann–Whitney-U test. When more than two groups were compared at different time points, a two-way ANOVA was used for parametric samples followed by a Holm–Sidak's multiple comparison test. For comparison of more than 2 groups with non-parametric samples a Kruskal–Wallis test was used followed by a Dunn's multiple comparison test. Proportions were compared using a Chi-square test. Values of *p* < 0.05 were considered statistically significant.

**Author Contributions:** Conceptualization, A.M.G., K.T. and C.T.; Data curation, A.M.G.; Formal analysis, A.M.G.; Funding acquisition, C.T.; Investigation, A.M.G., C.S. and K.T.; Methodology, A.M.G., K.T. and C.T.; Project administration, A.M.G.; Resources, K.T. and C.T.; Supervision, K.T. and C.T.; Visualization, A.M.G.; Writing—original draft, A.G.; Writing—review and editing, G.J., O.D., C.L., C.W.H., T.S.-R., K.T., and C.T. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was funded by Deutsches Zentrum für Herz-Kreislaufforschung, gran<sup>t</sup> number DZHK FKZ: 81X3200203.

**Conflicts of Interest:** The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
