**5. Conclusions**

Femoral artery ligated ApoE−/− mice on HFD with running wheel training is a suitable model to simulate exercise induced collateral growth. This experimental set-up may provide a model for investigating molecular training effects on arteriogenesis.

**Author Contributions:** A.B., K.T., and T.S.-R. designed the experiments. A.B., J.V., D.N. and K.T. interpreted the findings. A.B. and K.T. wrote the first draft of the manuscript. A.B and K.T. analyzed and performed experiments, A.B. performed statistical analyses; D.G., J.V., D.N., and T.S.-R. discussed the results and revised the manuscript. All authors edited and approved the manuscript.

**Funding:** This research was funded by the Anna-Maria and Uwe-Karsten Kühl Foundation (T0188/28514/2016, Bad Nauheim, Germany to K.T.).

**Acknowledgments:** The authors thank Christina Reschke and Brigitte Matzke for excellent technical assistance and Amir Kauveh Panah for proofreading the manuscript.

**Conflicts of Interest:** The authors declare no conflict of interest.
