**Jorge Otero 1,\*, Ivan Felis 2, Miguel Ardid <sup>1</sup> and Alicia Herrero <sup>3</sup>**


Received: 31 March 2019; Accepted: 23 April 2019; Published: 26 April 2019

**Abstract:** Hadrontherapy makes it possible to deliver high doses of energy to cancerous tumors by using the large energy deposition in the Bragg-peak. However, uncertainties in the patient positioning and/or in the anatomical parameters can cause distortions in the calculation of the dose distribution. In order to maximize the effectiveness of heavy particle treatments, an accurate monitoring system of the deposited dose depending on the energy, beam time, and spot size is necessary. The localized deposition of this energy leads to the generation of a thermoacoustic pulse that can be detected using acoustic technologies. This article presents different experimental and simulation studies of the acoustic localization of thermoacoustic pulses captured with a set of sensors around the sample. In addition, numerical simulations have been done where thermo-acoustic pulses are emitted for the specific case of a proton beam of 100 MeV.

**Keywords:** hadrontherapy; acoustic localization; Bragg peak; thermoacoustic; piezoelectric ceramic
