**Prevalence of Medication-Dietary Supplement Combined Use and Associated Factors**

**Ignacio Aznar-Lou 1,2,\*, Cristina Carbonell-Duacastella 1, Ana Rodriguez 3, Inés Mera 3 and Maria Rubio-Valera 1,2,4**


Received: 27 August 2019; Accepted: 5 October 2019; Published: 15 October 2019

**Abstract:** Introduction: The use of medication has increased in recent years in the US while the use of dietary supplements has remained stable but high. Interactions between these two kinds of products may have important consequences, especially in the case of widely used medications such as antihypertensives and antibiotics. The aim of this paper is to estimate the prevalence of potentially serious drug–dietary supplement interactions among tetracyclines, thiazides, and angiotensin II receptor blocker users by means of the NHANES 2013–2014 dataset. Methods: Data from 2013–2014 NHANES were obtained. Potential interactions analysed were tetracyclines with calcium, magnesium, and zinc, thiazides with vitamin D, and angiotensin II receptors blockers with potassium. Prevalence was calculated for each potential interaction. Logistic regression was used to assess associated factors. Results: 864 prescriptions issued to 820 patients were analysed. Overall prevalence of potential interaction was 49%. Older age and higher educational level were strongly associated with being at risk of a potential interaction. Factors such as age, race, civil status, citizenship, country of birth, BMI, and physical activity did not show notable associations. Conclusions: Healthcare professionals should be aware of other medical products when they prescribe or dispense a medication or a dietary supplement, especially to the older population and people with a higher educational level.

**Keywords:** prevalence; interactions; dietary supplements; antibiotics; antihypertensive medication
