**E**ff**ects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD**

**Sonali Nashine 1 and M. Cristina Kenney 1,2,\***


Received: 2 February 2020; Accepted: 23 April 2020; Published: 29 April 2020

**Abstract:** Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial-Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we summarize the varied effects of MDPs on cellular and mitochondrial health, which establish the merit of MDPs as therapeutic targets for AMD. We argue that further research to delve into the mechanisms of action and delivery of MDPs may advance the field of AMD therapy.

**Keywords:** MDPs; mitochondrial-derived peptides; Humanin; HNG; SHLPs; MOTS-c; Age-related Macular Degeneration (AMD); neuroprotection; RPE; mitochondria
