**Periodontal Disease in Patients Receiving Dialysis**

**Yasuyoshi Miyata 1,\*, Yoko Obata 2, Yasushi Mochizuki 1,3, Mineaki Kitamura 2,3, Kensuke Mitsunari 1, Tomohiro Matsuo 1, Kojiro Ohba 1, Hiroshi Mukae 4, Tomoya Nishino 2, Atsutoshi Yoshimura 5 and Hideki Sakai 1,3**


Received: 9 June 2019; Accepted: 1 August 2019; Published: 3 August 2019

**Abstract:** Chronic kidney disease (CKD) is characterized by kidney damage with proteinuria, hematuria, and progressive loss of kidney function. The final stage of CKD is known as end-stage renal disease, which usually indicates that approximately 90% of normal renal function is lost, and necessitates renal replacement therapy for survival. The most widespread renal replacement therapy is dialysis, which includes peritoneal dialysis (PD) and hemodialysis (HD). However, despite the development of novel medical instruments and agents, both dialysis procedures have complications and disadvantages, such as cardiovascular disease due to excessive blood fluid and infections caused by impaired immunity. Periodontal disease is chronic inflammation induced by various pathogens and its frequency and severity in patients undergoing dialysis are higher compared to those in healthy individuals. Therefore, several investigators have paid special attention to the impact of periodontal disease on inflammation-, nutrient-, and bone metabolism-related markers; the immune system; and complications in patients undergoing dialysis. Furthermore, the influence of diabetes on the prevalence and severity of manifestations of periodontal disease, and the properties of saliva in HD patients with periodontitis have been reported. Conversely, there are few reviews discussing periodontal disease in patients with dialysis. In this review, we discuss the available studies and review the pathological roles and clinical significance of periodontal disease in patients receiving PD or HD. In addition, this review underlines the importance of oral health and adequate periodontal treatment to maintain quality of life and prolong survival in these patients.

**Keywords:** periodontal disease; peritoneal dialysis; hemodialysis; immune response; diabetes
