*2.3. Meshing Configurations and Mesh Independency Test*

ICEM-CFD software was employed to generate the mesh of fluid domain. The regions of valve and aortic sinus were discretized with locally refined tetrahedral elements. In the remaining domain (upstream and downstream sections), the hexahedral mesh was used in order to limit the numerical diffusion. One of the mesh independency tests is shown in Table 1. The maximum velocity value at central and lateral orifices were used to check the mesh independency in all cases [17,18]. The total number of cells chosen was equal to 850,131.

