**2. Overview of the Endogenous Cannabinoid System**

Since its discovery in the 80s, the cannabinoid system has been extensively studied and described as being a relevant modulator of numerous physiological and pathological functions. This system comprises endogenous cannabinoids (endocannabinoids, EC), their receptors (CB), and the enzymes responsible for their synthesis and degradation. EC have a multifaceted role: in physiological conditions as psychoactive, analgesic, antiemetic, anti-inflammatory, vasorelaxant, orexigenic [19–22] and in a myriad of pathological states such as neurodegenerative disorders [23–25], myocardial infarction [25], liver fibrosis [26], and cancer [27,28]. Therefore, pharmacologic intervention of the EC system is a promising strategy for the management of many diseases. In fact, a substantial number of pharmacological agents that interfere with this system has been developed to date. Herein, we describe the most recent findings on the EC system, focusing on the pathogenesis of liver disease.
