3.3.4. Antimycobacterial Activity

In a study conducted by Basile et al. [52], the acetone extracts of *S. italica* leaves and flowers exhibited antibacterial activity against various strains of *Pseudomonas aeruginosa, Proteus mirabilis, Salmonella typhi* and *Proteus vulgaris*. Moreover, Askun et al. [53] reported the antibacterial and antimycobacterial activity of different *Sideritis* spp. The authors found that the methanolic extract of *S. leptoclada* exhibited antibacterial activity, with an MIC of 640 μg/mL on *Enterobacter aerogenes* and *Salmonella typhimurium*. A low mycobacterial activity was observed by the extracts of *S. albiflora* and *S. leptoclada* with an MIC of 1568 μg/mL. A similar result was observed in the present study with the *S. perfoliata* extract exhibiting an MIC greater than 1000 μg/mL.
