*2.2. Animals*

ICR mice [21] were obtained from Nara Biotech Co. (Pyeongteak, Korea). Their gender, age, and body weight were male, 6 weeks, and 25–30 g. The mice were housed in cages (five mice/cage) under specific pathogen-free conditions (21–24 ◦C and 40–60% relative humidity) with a 12 h light/dark cycle. In addition, they were given free access to standard rodent food (Orientbio Inc., Seongnam, Korea) and water. All animal experiments were approved by the Committee of Animal Care and Experiment of Chungnam National University (Daejeon, Korea) with a reference number (CNU-00973) and carried out following the guidelines of the Animal Care and Use Committee at Chungnam National University.
