*2.5. Statistical Analysis*

Each experiment was performed at least three times on different days and results were expressed as the mean ± standard error (SE) of different assays. GraphPad Prism v.6 (GraphPad Software, San Diego, CA, USA) was required to perform data analyses, nonlinear regressions, and statistics (such as two-way ANOVA or one-way ANOVA). Statistical differences were detected by comparing IC50 values of urolithin A and reference compounds using Student's *t*-test.
