*2.1. Reagents and Chemicals*

Urolithin A (3,8-dihydroxyurolithin) (Figure 1) was purchased from Toronto Research Chemicals (TRC, Toronto, ON, Canada). Neuro-2a (N2a) cell line was provided from the American Type Culture Collection (ATCC, Manassas, VA, USA), while Monoamine oxidase A (MAO-A), 5,5- -dithiobis-(2-nitrobenzoic acid) (DTNB), Tris, galantamine, levodopa (l-DOPA), tyramine, horseradish peroxidase, 2,2- -azobis(2-methyl-propionamidine)-di-hydrochloride (AAPH), hydrogen peroxide (30% *w*/*w*), 2,4,6-Tris(2-pyridyl)-1,3,5-triazine (TPTZ), 2- ,7- -dichloro-dihy-drofluorescein diacetate (DCFH-DA), 3-(4,5-Dimethyl-2-thiazolyl)-2,5- diphenyltetrazolium bromide (MTT), 6-hydroxy-2,5,7,8-tetra-methylchromane-2-carboxylic acid (Trolox), bovine serum albumin (BSA), vanillic acid, 4-aminoantipyrine, penicillin, streptomycin, tyrosinase, thiobarbituric acid (TBA), trichloroacetic acid (TCA), bicinchoninic acid (BCA), and pyrogallol were obtained from Sigma-Aldrich (Madrid, Spain). Clorgyline and α-kojic were from Cymit química (Barcelona, Spain). Na2CO3, HCl, NaCl, dimethyl sulfoxide (DMSO), MeOH, and potassium phosphate were supplied from Panreac (Barcelona, Spain). Dulbecco's modified Eagle's medium (DMEM), phosphate-buffered saline (PBS), and fetal bovine serum (FBS) were acquired from Gibco (Invitrogen, Paisley, UK).

**Figure 1.** Structure of Urolithin A. Synonyms: 3,8-Dihydroxyurolithin; 3,8-Hydroxydibenzo-α-pyrone; 2- ,7-Dihydroxy-3,4-benzocoumarin; δ-Lactone 2- ,4,4- -Trihydroxy-2-biphenylcarboxylic acid.
