*2.4. Bioavailability Study of M. koenigii-Derived Active Constituents*

An in vivo pharmacokinetic study revealed that after oral administration of the bioactive compounds at the rate of 0.1 gm/kg body weight (b.w.), the maximum systemic concentration (Cmax) of koenimbine was 1.81 ± 0.55 μM and koenidine was 2.82 ± 0.53 μM, and the time required to reach the maximum concentration was 49.8 ± 8.4 min and 240 ± 0.00 min, respectively [58]. Bhattacharya et al. demonstrated the bioavailability of mahanine—another important bioactive compound of *M. koenigii*—in mice through blood serum estimations based on high-performance liquid chromatography (HPLC) analysis. Mahanine, at a dose of 100 mg/kg of body weight, was found to take 60 min to reach the maximum concentration in blood serum [59].
