**4. Conclusions**

This study showed that 58% of the total *Aloe vera* leaf weight corresponds to inner fillet, but the green rind also accounted for a considerable percentage. The fillet consisted mainly of moisture, followed by dietary fibre and available carbohydrates (mainly glucose and fructose). Malic acid, which is an excellent freshness indicator, and α-tocopherol, a powerful fat-soluble chain-breaking antioxidant, were detected in high amounts in this jelly-like parenchyma. Based on the glycosidic-linkage composition, it was concluded that the fillet sample is composed mainly by mannans, possibly acemannan.

The three leaf samples revealed similar phenolic profiles, with predominance of chromones (aloesin and 2'-*p*-methoxycoumaroylaloresin) and anthrones (aloin A and B, malonyl aloin A and B, and 10-hydroxyaloin A and B). The highest contents of phenolic compounds were found in the mucilage and rind extracts, which also revealed interesting antioxidant properties. On the other hand, the flower extract was rich in apigenin glycoside derivatives, effective against the multidrug-resistant *P. aeruginosa*, and capable of inhibiting the activity of the enzyme tyrosinase. The fillet, rind, and flower extracts also showed a powerful antifungal activity against *A. flavus*, *A. niger*, *P. funiculosum*, and *C. albicans*, higher than that of ketoconazole. Therefore, all the studied *Aloe vera* samples present high potential to be exploited by food or cosmeceutical industries.

**Supplementary Materials:** The following are available online at http://www.mdpi.com/2076-3921/8/10/444/s1, Table S1. Moisture, organic acids and phenolic compounds composition of *Aloe vera* leaf (fillet, mucilage, and rind) and flower.

**Author Contributions:** Investigation, M.A.-O., J.P., L.B., S.P.S., E.C., M.S., and M.A.C.; Methodology, J.P., A.C., ´ A.M., and R.C.C.; Supervision, J.P. and I.C.F.R.F.; Writing—original draft, M.A.-O., J.P., and L.B.; Writing—review & editing, M.S., M.A.C., and I.C.F.R.F.

**Funding:** The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and FEDER (European Regional Development Fund) under Programme PT2020 for financial support to CIMO (UID/AGR/00690/2019) and the research contracts of J. Pinela, R.C. Calhelha, and L. Barros (national funding by FCT, through the institutional scientific employment program-contract); to the Project AllNat—POCI-01-0145-FEDER-030463 (PTDC/EQU-EPQ/30463/2017), funded by FEDER funds through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI)—and by national funds through FCT/MCTES; and to FEDER-Interreg España-Portugal programme for financial support through the project 0377\_Iberphenol\_6\_E.

**Acknowledgments:** The authors are grateful to the company "aCourela do Alentejo" for having supplied the plant material.

**Conflicts of Interest:** The authors declare no conflict of interest.
