3.2.1. IDP-Encoding mRNAs

A robust study monitoring gene expression in *Saccharomyces cerevisiae* (with similar trends detected for human genes [205]) demonstrated that mRNAs encoding sequences categorized as "highly unstructured" have lower half-lives than mRNAs encoding more structured proteins, having a comparable number of transcription factors regulating them [206]. One of the reasons for the increased mRNA decay is hypothesized to be the short poly(A) tails observed in IDP-encoding mRNAs, that foment RNA degradation pathways. Moreover, other factors related to transcript instability, like the binding of RNA-binding PUF proteins (that usually facilitate deadenylation and subsequent RNA clearance [209,210]) were found to be increased in mRNA coding for disordered proteins [206].
