**2. Review**

Below I address five key points or questions that address the key demands on a highly integrated cellular stress control point, namely: (1) A broad interpretation of the concept of the epiproteome; (2) How an organism can communicate between (and marshal) sets of proteins that need to respond to stress while also integrating the, on occasion conflicting, demands of distinct but simultaneous stresses; (3) Are there some key exemplars in plants and animals that point towards solutions to meet the demanding challenge of multiple stresses? (4) What are the characteristics required for a node that can successfully integrate response to simultaneous challenges? (5) How can multiple diverse signals be coordinated in real-time to deliver a coherent response?
