*4.1. Bioinformatics Analysis*

Disorder and disordered binding site predictions were performed with the IUPred2A online prediction tool (https://iupred2a.elte.hu/) [39] which incorporates the IUPred and Anchor predictors. RNA binding regions located in disordered regions were predicted using the DisoRDPbind tool (http://biomine.cs.vcu.edu/servers/DisoRDPbind/) [40]. Cancer-related single nucleotide polymorphisms in the long conserved IDR regions were collected from the BioMuta v2.0 [41] and COSMIC databases [42].
