**2. Results and Discussion**

Our dataset contains a total of 23,452 and 2412 residues in non-ribosomal and ribosomal protein–RNA complexes. Among them, 1175 (5%) and 155 (6.4%) residues are found to be in DOT regions in non-ribosomal and ribosomal complexes, respectively. The residues binding with RNA are obtained by using 3.5 and 6 Å distance cut-offs and similar trends are obtained. Therefore, we have presented the results with 3.5 Å and those for 6 Å are shown in supplementary material.
