*4.2. Other Complexes of Ordered and Disordered Proteins*

As a reference, two other datasets of protein complexes were used. A set of complexes formed exclusively by ordered single-domain protein interactors was taken from [28]. These 688 complexes (see Supplementary Table S3) are formed via autonomous folding followed by binding, that is, both interacting protein chains adopt a stable structure in their monomeric forms, prior to the interaction. A set of 772 complexes with an IDP interacting with ordered domains was taken from the database of Disordered Binding Sites (DIBS) database [23]. These complexes (see Supplementary Table S4) are formed via coupled folding and binding, where the IDP adopts a stable structure in the context of the interaction.
