**4. Conclusions**

A new analytical methodology based on μ-MSPD-GC–MS/MS has been proposed for the first time for the simultaneous analysis of 14 multiclass organic UV filters in cosmetic and personal care products. The main parameters a ffecting μ-MSPD extraction have been optimized to obtain the highest extraction efficiency. Under the optimal conditions, which implies the use of Florisil as the dispersing agen<sup>t</sup> and 1 mL of ACN as elution solvent, the method was successfully validated in terms of linearity, accuracy and precision. The proposed methodology was extended to other PCPs families, including fragrance allergens, preservatives, plasticizers and synthetic musks comprising a total of 78 compounds. Finally, to show the method suitability, it was applied to a broad range of real cosmetic samples present on the market, including sunscreen, make up, and hair-care products, among many others. In summary, the developed methodology provides a suitable, green, and fast tool to determine a broad range of cosmetic ingredients in a wide variety of cosmetic products, allowing simultaneous analysis of 78 compounds with very di fferent chemical nature in a single extraction and chromatographic run.

**Supplementary Materials:** The following are available online at http://www.mdpi.com/2297-8739/6/2/30/s1, Figure S1: Calibration plots for some representative compounds of each studied family, Table S1: Retention time and MS/MS transitions for the fragrance allergens, preservatives, plasticizers and synthetic musks.

**Author Contributions:** Conceptualization, M.L. and M.C.; methodology, M.L. and C.G.J.; validation, J.P.L., L.V. and M.L.; formal analysis, M.V., J.P.L., M.C. and L.V.; resources, M.L. and C.G.J.; writing—original draft preparation, M.L. and M.C.; writing—review and editing, M.C. and M.L.; supervision, M.L.; funding acquisition, M.L.

**Funding:** This research was supported by the project UNST10-1E-491 (Ministry of Science and Innovation, Spain). The authors belong to the Galician Competitive Research Group GPC2017/04 and to the CRETUS Strategic Partnership (ED431 2018/01). All these programs are co-funded by FEDER (EU).

**Conflicts of Interest:** The authors declare no conflict of interest.
