2.5.6. Other Genetic Variants

Zhu et al. performed admixture mapping for hypertension loci with genome-scan markers from individuals of African descent and European Americans (Family Blood Pressure Program). They found that chromosome 6q24 and 21q21 may contain genes associated with risk of hypertension in African Americans [27]. Another admixture mapping in African Americans was done in the Dallas Heart Study [100]. Researchers genotyped a panel of 2270 variants in a random sample of 1743 African Americans and found a missense variant in Vanin 1 (*VNN1*) (rs2272996) that was significantly associated with hypertension in African Americans. In the Candidate Gene Association Resource (CARe) consortium, a novel variant (rs7726475) on chromosome 5 (between the SUB1 Homolog, Transcriptional Regulator (*SUB1*) and Natriuretic Peptide Receptor 3 (*NPR3*) genes) and rs7726475 was found to be associated with both systolic and diastolic hypertension [101].

Finally, in the International Consortium for Blood Pressure Genome-Wide Association (19,775 subjects of African ancestry) [102], scientists identified a large number of variants associated with either systolic or diastolic hypertension in Africans, including: rs13082711 (*SLC4A7*) (SBP/DBP); rs419076 (*MECOM*), (SBP); rs13107325 (*SLC39A8*) (SBP/DBP); rs13139571 (*GUCY1A3-GUCY1B3*) (SBP/DBP); rs1173771 (*NPR3-C5orf23*) (SBP); rs11953630 (*EBF1*) (SBP/DBP); rs805303 (*BAT2-BAT5*) (DBP); rs7129220 (*ADM*) (SBP/DBP); rs633185 (*FLJ32810/TMEM133*) (SBP); rs2521501 (*FURIN-FES*) (SBP/DBP); rs17608766 (*GOSR2*) (SBP/DBP); rs1327235 (*JAG1*) (SBP/DBP); rs6015450 (*GNAS-EDN3*) (SBP/DBP); rs17367504 (*MTHFR-NPPB*) (SBP/DBP); rs3774372 (*ULK4*) (SBP/DBP); rs1458038 (*FGF5*) (SBP/DBP); rs1813353 (*CACNB2*) (SBP/DBP); rs11191548 (*CYP17A1-NT5C2*) (SBP/DBP); rs381815 (*PLEKHA7*) (SBP/DBP); rs3184504 (*SH2B3*) (SBP/DBP); rs1378942 (*CYP1A1-ULK3*) (SBP): rs12940887 (*ZNF652*) (SBP/DBP).
