2.5.3. *GPR25* and *SMOC1*

The Family Blood Pressure Program, which included 10,798 participants in 3320 families (3962 African Americans) observed a significant linkage on chromosome 7 (logarithm of odds [LOD] = 3.1) in African Americans people from the GenNet Network [98]. Sherva et al. identified loci contributing to arterial stiffness in a cohort 1251 Black people (HyperGEN study) [13]. Scientists identified two regions which were highly suggestive of linkage on chromosome 1 (LOD = 3.08), and another one on chromosome 14 (LOD = 2.42). Two candidate genes ((G Protein-Coupled Receptor 25 (*GPR25*), SPARC Related Modular Calcium Binding 1 (*SMOC1*)) were in the linked regions [13].
