2.5.3. Post-Operative Care after Implant Placement and Sacrifice

A broad spectrum antibiotic (penicillin G with was administered immediately after implant placement and again 48 h later by intramuscular injection (1 mL/5 kg). To control the plaque, Teeth were washed out with 2% chlorhexidine gluconate every day until study completion. Observations of experimental sites with regards to mucosal health, edema, maintenance of suture closure, and tissue infection or necrosis were made daily until suture removal. Suture materials were removed one week after implant placement. Experimantal animals were given a soft diet for two weeks, followed by a conventional regular diet. The animals were anesthetized and euthanized at eight weeks after implant placement by intravenous injection of concentrated sodium pentobarbital (Euthasol, Delmarva Laboratories Inc., Midlothian, VA, USA). Following euthanasia, block sections including implants, alveolar bone, and surrounding mucosa were collected.
