*Article* **Wireless Direct Microampere Current in Wound Healing: Clinical and Immunohistological Data from Two Single Case Reports**

**George Lagoumintzis 1,\*, Zoi Zagoriti 1, Mogens S. Jensen 2, Theodoros Argyrakos 3, Constantinos Koutsojannis 4 and Konstantinos Poulas 1,\***


Received: 17 July 2019; Accepted: 2 September 2019; Published: 5 September 2019

**Abstract:** Chronic pressure ulcers are hard-to-heal wounds that decrease the patient's quality of life. Wireless Micro Current Stimulation (WMCS) is an innovative, non-invasive, similar to electrode-based electrostimulation (ES) technology, that generates and transfers ions that are negatively-charged to the injured tissue, using accessible air gases as a transfer medium. WMCS is capable of generating similar tissue potentials, as electrode-based ES, for injured tissue. Here, through immunohistochemistry, we intended to characterize the induced tissue healing biological mechanisms that occur during WMCS therapy. Two single cases of bedridden due to serious stroke white men with chronic non-healing pressure ulcers have been treated with WMCS technology. WMCS suppresses inflammatory responses by decreasing the aggregation of granulocytes, followed by stimulating myofibroblastic activity and a new formation of collagen fibers, as depicted by immunohistochemistry. As a result, WMCS provides a special adjunct or stand-alone therapy choice for chronic and non-healing injuries, similar to electrode-based ES, but with added (i.e., contactless) benefits towards its establishment as a routine clinical wound healing regime.

**Keywords:** chronic wounds; electrical stimulation; direct microcurrent; non-invasive; pressure ulcer; wireless technology
