*Review* **Telomeres and Telomerase in Heart Ontogenesis,Aging and Regeneration**

#### **Denis Nalobin 1,\*, Svetlana Alipkina 1, Anna Gaidamaka 1, Alexander Glukhov 1,2 and Zaza Khuchua 2,3,4**


Received: 30 November 2019; Accepted: 14 February 2020; Published: 22 February 2020

**Abstract:** The main purpose of the review article is to assess the contributions of telomere length and telomerase activity to the cardiac function at different stages of development and clarify their role in cardiac disorders. It has been shown that the telomerase complex and telomeres are of grea<sup>t</sup> importance in many periods of ontogenesis due to the regulation of the proliferative capacity of heart cells. The review article also discusses the problems of heart regeneration and the identification of possible causes of dysfunction of telomeres and telomerase.

**Keywords:** cardiomyocytes; telomere length; telomerase activity; development; regeneration; reactive oxygen species
