*3.2. Adverse Events*

Since there was no treatment of the participants, the risk of inducing study-related adverse events was considered low. Nevertheless, some adverse events were recorded and included a cat bite during a veterinary visit, chronic urticaria, erythema, common cold, and pruritus (Table 2). The participant bitten by their cat during an immunization procedure at the veterinary practice was referred to their doctor and received prophylactic antibiotic treatment. They fully recovered from the wound after 1 week. Another participant #10 (excluded from analysis) suffered from an urticaria and presented with strong pruritus and wheal formation. The symptoms were treated with topical urea, macrogol-6-laurylether and fexofenadine-hydrochloride.

There were no severe adverse events observed in the cat population. Several minor clinical signs were noted upon immunization with Fel-CuMV and were judged to be normal vaccination reactions in cats. They disappeared within 72 h of administration. All reactions during and after injection of Fel-CuMV were less frequent on the second and third dosing occasions. There were no treatment related changes in body weight or temperature observed over the study period. Cat owners reported no change in the behavior or appearance (e.g., fur condition) of the cats.



**Table 2.** Adverse events.


*Viruses* **2020** , *12*, 288
