**Ina Balke and Andris Zeltins \***

Plant virology group, Latvian Biomedical Research and Study Centre, Ratsupites 1, LV1067 Riga, Latvia; inab@biomed.lu.lv

**\*** Correspondence: anze@biomed.lu.lv

Received: 30 January 2020; Accepted: 26 February 2020; Published: 28 February 2020

**Abstract:** Vaccination is one of the most effective public health interventions of the 20th century. All vaccines can be classified into different types, such as vaccines against infectious diseases, anticancer vaccines and vaccines against autoimmune diseases. In recent decades, recombinant technologies have enabled the design of experimental vaccines against a wide range of diseases using plant viruses and virus-like particles as central elements to stimulate protective and long-lasting immune responses. The analysis of recent publications shows that at least 97 experimental vaccines have been constructed based on plant viruses, including 71 vaccines against infectious agents, 16 anticancer vaccines and 10 therapeutic vaccines against autoimmune disorders. Several plant viruses have already been used for the development of vaccine platforms and have been tested in human and veterinary studies, suggesting that plant virus-based vaccines will be introduced into clinical and veterinary practice in the near future.

**Keywords:** plant virus; virus-like; vaccine platform; epitope; antigen; immune response
