**3. Prospects for Further Development of Tag**/**Catcher-Based CLP Display Technologies**

The Tag/Catcher conjugation system is able to fulfill many of the criteria important for obtaining a viral-like epitope display, as highlighted in Table 1. This was demonstrated through the development and success of the SpyTag/SpyCatcher-AP205 platform. However, there are more opportunities to explore. Adaptations in the modular vaccine design, such as the choice of backbone, particle size and antigen density, as well as the addition of appropriate intrinsic and extrinsic adjuvants, could aid in broadening the development of CLP-based vaccines. Additionally, practical aspects such as manufacturability, scalability and cost-effectiveness, can determine future downstream success, and therefore need to be taken into account during vaccine development. In the section below, we will discuss several aspects that should be considered when designing future Tag/Catcher CLP-based vaccines and highlight several unanswered questions and hypotheses that are yet to be experimentally validated.
