**5. Conclusions**

The essential oil of *P. caldense* presented mono- and sesquiterpene components, though not presented a major constituent. In addition, it showed low antifungal activity for *C. albicans* strains but was able to modulate the e ffect of standard drug (fluconazole) and decreased the virulence of these strains. In this way, the oil has in its composition constituents that are promising in the formulation of drugs used in the treatment of infectious diseases.

**Author Contributions:** Conceptualization, J.W.A.B., M.I., H.D.M.C. and M.F.B.M.-B.; Data curation, J.W.A.B., F.C.R., R.P.d.C., L.E.d.S., E.M.V., H.D.M.C. and M.F.B.M.-B.; Formal analysis, J.W.A.B., F.C.R., R.P.d.C. and L.E.d.S.; Methodology J.W.A.B., F.C.R., R.P.d.C., L.E.d.S., W.d.A., R.A.R., I.M.B., and E.M.V.; Supervision, M.I., H.D.M.C. and M.F.B.M.-B.; Methodology, C.F.B.; Writing—original draft, J.W.A.B., F.C.R., R.P.d.C. and L.E.d.S.; Writing—review & editing, M.I., E.M.V., H.D.M.C. and M.F.B.M.-B. All authors have read and agreed to the published version of the manuscript.

**Funding:** The authors thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) by research grants, Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP) by the concession of equipment and projects, and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for supporting research.

**Conflicts of Interest:** The authors declare no conflict of interest.
