**4. Conclusions**

In summary, we concisely synthesized potent antioxidant homoisoflavones, oleracones D (**1**) and F (**2**), from dihydrochalcone olereacone E (**3**), and investigated their potential lifespan extension properties. Our results may shed light on the development of isoflavone-based anti-aging medications.

**Supplementary Materials:** The following are available online at http://www.mdpi.com/2076-3417/9/19/4014/s1, Table S1: Comparative analysis of 1H NMR and 13C NMR of oleracone E. Table S2: Comparative analysis of 1H NMR and 13C NMR of oleracone F. Table S3: Comparative analysis of 1H NMR and 13C NMR of oleracone D.

**Author Contributions:** Conceptualization, Y.T.H. and D.S.C.; formal analysis, J.A.Y.; investigation, D.S.C. and J.A.Y.; data curation, C.L.; draft preparation, C.L. and D.S.C.; review and editing, Y.T.H.; supervision, Y.T.H.; project administration, Y.T.H.

**Funding:** This work was supported by the National Research Foundation of Korea (NRF) gran<sup>t</sup> (NRF-2017R1C1B1001826) and by the GRRC (Gyeonggi-do Regional Research Center) program of Gyeonggi province (GRRC-CHA2017-B02).

**Acknowledgments:** We thank Emeritus Young-Ger Suh (Seoul National University) for his helpful discussions in manuscript preparation.

**Conflicts of Interest:** The authors declare no conflict of interest.
