*Review* **Analysis of Biomolecules Based on the Surface Enhanced Raman Spectroscopy**

### **Min Jia 1,2, Shenmiao Li 3, Liguo Zang 1, Xiaonan Lu 3 and Hongyan Zhang 1,\***


Received: 28 August 2018; Accepted: 14 September 2018; Published: 15 September 2018

**Abstract:** Analyzing biomolecules is essential for disease diagnostics, food safety inspection, environmental monitoring and pharmaceutical development. Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for detecting biomolecules due to its high sensitivity, rapidness and specificity in identifying molecular structures. This review focuses on the SERS analysis of biomolecules originated from humans, animals, plants and microorganisms, combined with nanomaterials as SERS substrates and nanotags. Recent advances in SERS detection of target molecules were summarized with different detection strategies including label-free and label-mediated types. This comprehensive and critical summary of SERS analysis of biomolecules might help researchers from different scientific backgrounds spark new ideas and proposals.

**Keywords:** biomolecule; surface enhanced Raman spectroscopy (SERS); nanomaterial; analysis; identification; biology
