*2.1. Search Strategy and Eligibility*

We used the online database Web of Science (WOS) to identify research papers regarding interventions to treat children and adolescents with obesity. The search was conducted in June 2019 and included articles published between January 1991 and December 2018. The WOS database was selected because it is suitable for our objectives, including (1) 254 various disciplines [36], (2) Higher impact journals [37]. Moreover, WOS allows us to download a large amount of data with important information for our analysis, such as the number of times the papers were downloaded and research areas which were assigned by WOS.

The WOS database search, using keywords, was divided into two steps. Specialists in the field of nutrition and adolescent health found keywords related to "obesity" and "children". In step 1, they were used to collect research articles and reviews from WOS. The database search process is shown in Table S1. These papers were then downloaded under the .txt format and imported into STATA (version 14.0, STATA Corp., TX, the USA). Using a STATA syntax, we searched specifically for papers that included the terms "trial\*", and "intervention\*" in the title or abstract (step 2).

Papers written in languages other than English were excluded. Additionally, papers other than original research articles or reviews (e.g., editorial, book chapter, letters to the editor, or conference proceedings), and papers where the authors were anonymous or unlisted were also excluded from the current study (Figure S1).
