**Global Research Output and Theme Trends on Climate Change and Infectious Diseases: A Restrospective Bibliometric and Co-Word Biclustering Investigation of Papers Indexed in PubMed (1999–2018)**

**Fan Li <sup>1</sup> , Hao Zhou 2,3, De-Sheng Huang 2,4 and Peng Guan 2,\***


Received: 26 June 2020; Accepted: 14 July 2020; Published: 20 July 2020

**Abstract:** Climate change is a challenge for the sustainable development of an international economy and society. The impact of climate change on infectious diseases has been regarded as one of the most urgent research topics. In this paper, an analysis of the bibliometrics, co-word biclustering, and strategic diagram was performed to evaluate global scientific production, hotspots, and developing trends regarding climate change and infectious diseases, based on the data of two decades (1999–2008 and 2009–2018) from PubMed. According to the search strategy and inclusion criteria, a total of 1443 publications were found on the topic of climate change and infectious diseases. There has been increasing research productivity in this field, which has been supported by a wide range of subject categories. The top highly-frequent major MeSH (medical subject headings)/subheading combination terms could be divided into four clusters for the first decade and five for the second decade using a biclustering analysis. At present, some significant public health challenges (global health, and travel and tropical climate, etc.) are at the center of the whole target research network. In the last ten years, "Statistical model", "Diarrhea", "Dengue", "Ecosystem and biodiversity", and "Zoonoses" have been considered as emerging hotspots, but they still need more attention for further development.

**Keywords:** climate change; infectious diseases; bibliometric analysis; co-word analysis; biclustering; strategic diagram
