**Abbreviations**

HIF-1: hypoxia inducible factor-1; MG132: Z-Leu-Leu-Leu-al; Hsp90: heat-shock protein 90; VHL: Von Hippel-Lindau; Akt: oncogene from AKR mouse thymoma; PI3K: phosphoinositide 3-kinase; mTOR: mammalian target of rapamycin; p70S6K: p70 S6 kinase; 4E-BP1: initiation factor 4E-binding protein 1; RPS6: ribosomal protein S6; eIF4E: eukaryotic translation initiation factor 4E; VEGF: vascular endothelial growth factor; STAT3: signal transducer and activator of transcription-3; MAPK: mitogen-activated protein kinase; ERK: extracellular-signal-related kinase; LC3: light chain 3.
