*3.1. Materials*

Salternamide A (SA, Figure 1A) was dissolved in 100% DMSO and stored at −20 ◦C for subsequent analysis. Cobalt (II) chloride (CoCl2) and MG132 were purchased from Sigma-Aldrich (St. Louis, MO, USA). Antibodies for HIF-1α, Akt, phospho-Akt (Thr308), PI3K, phospho-PI3K (Tyr458/199), RPS6, phospho-RPS6 (Ser235/236), p70S6K1, phospho-p70S6K1 (Thr389), phospho-STAT3 (Tyr705), mTOR, phospho-mTOR (Ser2448), 4E-BP1, phospho-4E-BP1 (Thr37/46), eIF4E, phospho-eIF4E (Ser209), phospho-CDC2 (Thr161), CDC25C, phospho-CDC25C (Ser216), Chk1, phospho-Chk1 (Ser345), phospho-Chk2 (Thr168), caspase-3, caspase-8, caspase-9, cleaved caspase-3, cleaved caspase-8, and LC3B were purchased from Cell Signaling Technology (Danvers, MA, USA). Antibodies for ERK 1/2, phospho-ERK 1/2 (Thr202/Tyr204), STAT3, CDC2, cyclin B1, cyclin A, Bcl-2, and Bcl-xL were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). Antibodies for VHL, PARP, cleaved PARP, and Bim were purchased from BD Pharmingen™ (BD Biosciences, San Jose, CA, USA). Hsp90 antibody was purchased from Stressgen Bioreagents (Ann Arbor, MI, USA).
