*4.4. Bioethical Requirements*

All animal experiments were carried out in full accordance with the European Convention for the Protection of Vertebrate Animals, used for experimental and other scientific purposes (Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes), and the requirements of Sanitary Regulations 1.3.2322-08 "Safety of work with microorganisms of the III-IV pathogenicity groups and pathogens of parasitic diseases", and Veterinary Protocol No. VP-2016/8 were approved by bioethics of the State Research Center for Applied Microbiology and Biotechnology.
