*5.1. Search Strategy and Eligibility Criteria*

To identify appropriate studies for a network meta-analysis, two independent investigators (CWL and SJC) conducted a comprehensive electronic literature search of PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), Wiley, and ClinicalTrial.gov for trials published between January 1995 and September 2019, with a language restriction of English. The present study followed PRISMA recommendations. The terms and related synonyms "overactive bladder", "bladder overactivity", "detrusor overactivity", "urinary incontinence", "urgency", "urgent incontinence", "detrusor overactivity" and "Botulinum A toxin" or "OnabotulinumtoxinA" or "Botox" or "botulinumtoxin A" or "sacral neuromodulation" or "sacral nerve stimulation" or "percutaneous tibial nerve stimulation" or "posterior tibial nerve stimulation" were combined in the search strategy. MeSH terms, key words and other free terms were used for searching and Boolean operators (OR and AND) were used to combine the searches. The reference lists of the included articles, as well as the guidelines for the AUA and European Association of Urology were manually reviewed, and external peer reviewers were asked to contribute any additional trials.

Studies were considered eligible if they were randomized controlled trials that compared any dose of OnabotulinumtoxinA, SNM, and PTNS therapy with each other or a placebo, in adults with OAB syndrome with reported efficacy at 12 weeks follow-up. It was required that the studies provided detailed data on the treatments and outcomes of the participants.
