**1. Introduction**

Since the first injection of onabotulinumtoxinA (onaBoNTA) for a patient with detrusor sphincter dyssynergia in 1988, onaBoNTA has been extensively used in the treatment of lower urinary tract dysfunction [1]. At present, the intradetrusor injection of onaBoNTA is indicated for treating neurogenic and idiopathic overactive bladder (OAB) [2]. Although the intradetrusor injection of onaBoNTA is highly efficacious in the treatment of OAB and other sensory bladder disorders, some perioperative complications (e.g., pain, haematuria, increased post-void residual volume, acute urinary retention, and urinary tract infections) and inconvenience related to performing the cystoscopic procedure along with anesthesia, remain a concern [3]. Hence, researchers have attempted to deliver onaBoNTA by using different approaches to improve accessibility and decrease adverse effects in patients. This review examines these experimental studies of injection-free onaBoNTA delivery for the treatment of sensory bladder disorders.
