≥50% Symptom Improvement at 12 Weeks Follow-up

The network of eligible comparisons for >50% symptom improvement is shown in Figure 4D. There were eight studies that reported parameters including ≥50% improvement in symptoms at 12 weeks follow-up. Pair-wise comparisons with a RE model revealed all three modalities were more efficacious than the placebo. However, there was a significant inconsistency expected in ≥50% reduction of symptoms improvement. Therefore, network meta-analysis and ranking probability was not conducted with regard to this parameter.

**Figure 4.** Network of treatment comparisons between OnabotulinumtoxinA (Botox), sacral neuromodulation (SNM), percutaneous tibial nerve stimulation (PTNS) in regard to (**A)** urinary frequency/day, (**B)** incontinence, (**C**) urinary tract infection, and (**D**) ≥50% of symptoms improvement. The figure was generated using R 3.3.2 software.
