**5. Conclusions**

Altogether, our findings support the hypothesis that the chronic administration of curcumin may protect mice brains against the detrimental effects of ethanol, by serving as a strong antioxidant, anti-inflammatory, and antiapoptotic agent in vivo mice brains and in vitro cells.

**Author Contributions:** M.I designed and conducted the experiments, and wrote manuscript; K.S., and M.S.K. conducted the experiments; A.K., T.M., M.G.J., and S.U.R. conducted the statistical analysis, reviewed and edited the manuscripts; M.O.K. supervised and organized the final version of the manuscript. All of the authors reviewed and approved the paper.

**Funding:** This research was supported by the Brain Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Science—ICT (2016M3C7A1904391).

**Conflicts of Interest:** The authors declare no competing financial interests.
