*Brief Report* **rs2569190A**>**G in** *CD14* **is Independently Associated with Hypercholesterolemia: A Brief Report**

**Ali Salami 1, Christy Costanian 2,3 and Said El Shamieh 4,\***


Academic Editor: Maurice Van den Hoff

Received: 5 September 2019; Accepted: 28 October 2019; Published: 30 October 2019

**Abstract:** Many studies have assessed the implication of *cluster of differentiation 14* (*CD14*) molecules and its single nucleotide polymorphism rs2569190A>G with different complex diseases, such as diabetes and cardiovascular diseases (CVDs). In this study, we investigated the association of rs2569190A>G in *CD14* with cardiovascular disease risk factors (hypercholesterolemia and hypertension) in 460 individuals from the general Lebanese population (Middle Eastern multiethnic population). Using a multiple logistic regression model adjusted for six covariates (under additive and recessive assumptions), we found that the G allele of rs2569190 in *CD14* was associated with increased levels of total cholesterol (OR = 3.10, *p* = 0.009), low-density lipoprotein cholesterol (OR = 3.87, *p* = 0.003), and decreased levels of high-density lipoprotein cholesterol (OR = 0.38, *p* = 0.001). In contrast, no significant relationship was found with hypertension. Thus, we concluded that rs2569190G in *CD14* is associated with a higher risk of developing hypercholesterolemia.

**Keywords:** hypercholesterolemia; *cluster of di*ff*erentiation 14*; rs2569190A>G; single nucleotide polymorphisms; association analysis
