*2.3. Lipid Regulators*

In this group, the pattern observed with both previous therapeutic groups was not so clear, with median concentrations similar in all trophic levels for acute toxicity. Observing these data, SIM was clearly the pharmaceutical, which promoted toxicity at lower concentrations for invertebrates (160 ng <sup>L</sup>−1) and fish (765 μg <sup>L</sup>−1) [26,56]. However, data on chronic toxicity, only available for GEM in two trophic levels, showed that the highest toxicity regarded fish (1.5 μg <sup>L</sup>−1), followed by invertebrates (78.0 μg <sup>L</sup>−1) [51,85].
