**5. Conclusions**

In the present study with *F. asiaticum*, the conserved WCC photoreceptor orthologs, namely FaWC1 and FaWC2, have been characterized. Both FaWC1 and FaWC2 are required for perceiving light signals to regulate UV resistance, secondary metabolism, and sexual reproduction. However, FaWC1 and FaWC2 performed diverged roles in virulence expression. Based on the genetics data, we conclude that the WCC orthologs in *F. asiaticum* are responsible for light signaling to adapt to the environmental niche; meanwhile, moonlighting functions of the individual component FaWC1 are required for regulating pathogenicity in a light-independent manner.

**Supplementary Materials:** The following are available online at http://www.mdpi.com/2076-2607/8/3/365/s1, Table S1: All the primers used in the mutant generating and diagnosis PCR reactions.

**Author Contributions:** Conceptualization, P.Z. and L.X.; methodology, P.Z., Y.J. and Y.T.; software, Y.T.; validation, P.Z., Y.T. and L.X.; formal analysis, P.Z.; investigation, Y.T., P.Z., Z.L., Y.Q., L.H., N.Z. and Y.W.; resources, P.Z. and L.X.; data curation, Y.T. and P.Z.; writing—original draft preparation, Y.T. and P.Z.; writing—review and editing, Y.T., P.Z., H.N., Y.J. and L.X.; visualization, Y.T. and P.Z.; supervision, P.Z. and Y.J. and L.X.; project administration, P.Z. and L.X.; funding acquisition, P.Z. and L.X. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research was financially supported by the National Key Research and Development Program of China (2016YFD0400105), National Natural Science Foundation of China (31972121), Shanghai Municipal Science and Technology Commission (18391901400), and Shanghai Municipal Agricultural and Rural Committee (2019-02-08-00-02-F01146).

**Acknowledgments:** We thank Weihua Tang (Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China) for kindly providing plasmid pflu6.

**Conflicts of Interest:** The authors declare no conflict of interest.
