**5. Conclusions**

In this study, male and female specimens of *Pelagia noctiluca* from the Strait of Messina were chemically characterized with respect to their nutritional and nutraceutical properties, taking into consideration both their bells and oral arms. Overall, the gross energy content was higher in bells rather than oral arms, while proteins and total phenolics were inversely concentrated. The fatty acid composition included important MUFAs, such as oleic acid, and PUFAs, such as EPA and DHA. Also, antioxidant inorganic elements were revealed. Both chemical classes varied in dependence of the investigated jellyfish part. In fact, SFAs were more concentrated in bells than oral arms, whereas PUFAs were distributed in the exact opposite way. MUFAs appeared to be equally present in both organs. On the other hand, major elements and trace elements demonstrated an opposite behavior, being the latter most accumulated in oral arms than bells.

With the exception of the significantly high energy contents and total phenolic contents observed in female organisms, no remarkable differences that could be ascribed to the variable "sex" were highlighted for the other compound classes. With the appropriate precautions, obtained results may support the potential employment of *P. noctiluca* as aquafeed or food supplement.

**Supplementary Materials:** The following are available online at http://www.mdpi.com/1660-3397/17/3/172/s1, Table S1: Summary output of the two-way ANOVA with replication analysis performed on biometric data from *P. noctiluca.* SS: sum-of-squares; df: degrees of freedom; MS: mean squares. Table S2. Summary output of the two-way ANOVA with replication analysis performed on gross energy contents from *P. noctiluca.* SS: sum-of-squares; df: degrees of freedom; MS: mean squares. Table S3. Summary output of the two-way ANOVA with replication analysis performed on crude protein contents derived from *P. noctiluca*. SS: sum-of-squares; df: degrees of freedom; MS: mean squares. Table S4. Summary output of the two-way ANOVA with replication analysis performed on total polyphenol levels obtained from *P. noctiluca.* SS: sum-of-squares; df: degrees of freedom; MS: mean squares. Table S5: Performance of the ICP-MS method in terms of linearity, LOD, LOQ, intra- and interday repeatability (*n* = 3), and accuracy.

**Author Contributions:** R.C., G.C., and A.A.: Project Design and Writing; R.L.V.: Sample Collection and Biometric Data Collection; G.B. (Giovanni Bartolomeo): Phenolics Analysis; G.B. (Giuseppe Bua): Elemental Analysis; A.F.: Calorimetry Analysis; S.S.: Biometric Data Collection; T.G.: Protein Analysis; R.R.: Lipid Analysis; G.D. and N.S.: Project Supervision.

**Funding:** This research received no external funding.

**Conflicts of Interest:** The authors declare no conflict of interest.
