*3.1. Protein-Synthesis Inhibitors*

Streptomycin, a protein-synthesis inhibitor and a well-established anti-TB drug, has been shown to be effective in treating MTB patients, but its use is limited because of it not being an oral drug and the toxicities associated with it for prolonged use [25]. Several novel protein-synthesis inhibitors that have been approved as antibacterials were also tested for their antimycobacterial activity. The oxazolidinone [26] class of compounds, despite its limitations of myelotoxicity, hold a significant position in the treatment of MDR and Extensively drug-resistant tuberculosis (XDR)TB in the current anti-TB treatment regimen. Linezolid [27,28] is currently a part of the drug regimen for the treatment of MDR TB, XDR and non-responding TB (NRTB), while newer oxazolidinones like Posizolid [29–31] and Sutezolid [32,33] have been tested in advanced clinical trials. Newer oxazolidinones like the Delpazolid [34] and Contezolid [35] are also in clinical trials.
