3.2.1. MenD

Studies by Fang et al. identified two compounds, methyl succinylphosphonate (2) and succinylphosphonate (1), that inhibit *M. tb* MenD at a Ki of 0.7 and 16 μM, respectively [115]. These inhibitors are structural analogues of the substrate 2-oxoglutarate and bind covalently to MenD. The resolution of the three-dimensional structure of *M. tb* MenD by NMR will support target-based drug design [119].
