**4. Conclusions**

Several HDT approaches are currently being tested in a number of preclinical and clinical trials as adjuvants complementing conventional anti-TB treatment. Clinical trial results provided in the near future will present an important milestone for the implementation of HDT in routine clinical use. While representing a promising therapeutic approach in theory, most compounds targeting mycobacterial virulence factors lack in vivo proof of principle data.

**Author Contributions:** All of the authors participated in writing and reviewing the manuscript. All authors have read and agreed to the published version of the manuscript.

**Funding:** J.R. receives funding from the Thematic Translational Unit Tuberculosis (TTU TB, grant number TTU 02.806 and 02.905) of the German Centre of Infection Research (DZIF), the German Research Foundation (DFG RY 159, CRC1403), the Centre for Molecular Medicine Cologne (ZMMK–CAP8). J.R. has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 853989. The JU receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA and Global Alliance for TB Drug Development Non Profit Organisation, Bill & Melinda Gates Foundation, University Of Dundee.

**Conflicts of Interest:** The authors declare no conflicts of interest.
