3.2.2. MenE

Due to the instability of OSB, efforts to create MenE inhibitors were mainly focused on the inhibition of the assembly of the OSB-AMP intermediate. Lu et al. identified three potential MenE inhibitors using the OSB as a scaffold [50,120]. In these inhibitors, the AMP moiety was replaced with a bioisosteres sulphamate, a sulphamide, and a vinyl sulphonamide group [120]. The vinyl sulphonamide compound was the most potent with IC50 of 5.7 μM against the purified *M. tb* MenE enzyme [50].
