*4.1. General Methods*

Chemicals and solvents were purchased from Merck (Merck Life Science S.r.l., Milan, Italy) and used without further purification. Trimethylsilyldiazomethane 10% solution in hexane (TCI Europe N.V.) was purchased from Zentek Srl (Milan, Italy). Novozyme 435 (Novozymes) was purchased from Strem Chemicals Inc. (Bischheim, France). TLC analyses were performed on Macherey Nagel pre-coated TLS sheets Polygram® SIL G/UV254 purchased from Chimikart s.r.l. (Naples, Italy). 1H and 13C NMR spectra were recorded on a 400 or 500 MHz spectrometer in CDCl3 solution at r.t. The chemical shift scale was based on internal tetramethylsilane. GC/MS analyses were performed using an HP-5MS column (30 m × 0.25 mm × 0.25 μm, Agilent Technologies Italia Spa, Cernusco sul Naviglio, Italy). The following temperature program was employed: 50 ◦C/10 ◦C min−1/250 ◦C (5 min)/50 ◦C min−1/300 ◦C (10 min). The samples for GC/MS were treated with MeOH and trimethylsilyldiazomethane 10% in hexane, to derivatize carboxylic acids by transformation into the respective methyl esters.
