*4.6. Determination of Aqueous Solubility and Stability*

Aqueous solubility and stability were conducted with the methods we used in a previous study [20]. For aqueous solubility assay, the tested compound was vortexed in distilled deionized H2O for 1 h at 25 ◦C. The mixture was analyzed with UPLC. For stability assay, a stock of the tested compound (100 mg/mL in dimethyl sulfoxide) was diluted 100-fold to a concentration of 1 mg/mL in 50 mM of Tris buffer at pH 8.0. Then, samples were taken out for the UPLC analysis at the determined interval times.
