*3.2. Preparation of NOTA-PODS and NODAGA-PODS*

The macrocyclic chelator NHS ester (10.32 μmol), was added solid to a solution of PODS (6.88 μmol) in DMF (400 μL) and DIPEA (7.2 μL, 41.3 μmol). The clear solution was incubated in a thermo shaker at 23 ◦C for 2 h (900 rpm). The product was analyzed by RP–HPLC and either purified by RP–HPLC (Gradient 1a) or used for the next reaction without further purification.

NOTA-PODS = Analytical RP–HPLC (Gradient 1): Rt: 12:15 min:sec; ESI–HRMS: [M + H]<sup>+</sup> (*m*/*z*) calcd: 827.9, found 827.3633.

NODAGA-PODS = Analytical RP–HPLC (Gradient 1): Rt: 12:13 min:sec; ESI–HRMS: [M + H]<sup>+</sup> (*m*/*z*) calcd: 899.9, found 899.3895.
