4.8.1. Evaluation of [111In]**2** in Mice Pretreated with **5**

Four female nude BALB/c mice bearing subcutaneous LS174T tumor xenografts (mean size of 111.8 <sup>±</sup> 29.7 mm3) were administered i.v. with **<sup>5</sup>** (100 <sup>μ</sup>g) in PBS (50 <sup>μ</sup>L). The control group for **<sup>5</sup>** was nude BALB/c mice bearing LS174T subcutaneous tumor xenografts (mean size of 136.7 <sup>±</sup> 13.1 mm3). After 24 h, [111In]**2** (mean 59 MBq, 12 μg, 9.7 nmol) in 0.2 M ammonium acetate pH 5 (50 μL) was administered i.v. SPECT/CT images were obtained 2 and 22 h p.i.
