**Preface to "Advances in Cross-Coupling Reactions"**

Metal-catalyzed cross-coupling reactions stand among the most important synthetic tools in Chemistry for the preparation of a wide variety of organic compounds, from bioactive compounds to new organic materials. This methodology relies on the high versatility, the chemoselectivity, and the stereoselectivity to build most of the carbon–carbon type bonds, particularly between unsaturated carbons, and carbon–heteroatom bonds using heteronucleophiles. Therefore, a variety of organic compounds can be used and the reactivity tuned by choosing an adequate metal catalyst and ligands. As a consequence, this methodology has been applied in industrial processes using classical and non-classical reaction conditions. Despite these remarkable synthetic properties, new ways to extend the selectivity and improve the efficiency and sustainability of the coupling reactions are continuously being discovered. This Special Issue aims to highlight the most recent advances in cross-coupling reactions. This Special Issue will cover new leaving groups, nucleophiles, catalysts, and non-classical reaction conditions. We hope that this Special Issue will stimulate authors and readers as much as it has the Editors.

> **Jos´e P´erez Sestelo, Luis A. Sarandeses** *Editors*
