Reprint
mTOR Signaling in Metabolism and Cancer
Edited by
December 2020
204 pages
- ISBN978-3-03943-553-1 (Hardback)
- ISBN978-3-03943-554-8 (PDF)
This book is a reprint of the Special Issue mTOR Signaling in Metabolism and Cancer that was published in
Biology & Life Sciences
Medicine & Pharmacology
Summary
The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this Special Issue summarize the current understanding of the mTOR pathway and its role in the regulation of tissue regeneration, regulatory T cell differentiation and function, and different types of cancer including hematologic malignancies, skin, prostate, breast, and head and neck cancer. The findings highlight that targeting mTOR pathway is a promising strategy to fight against certain human diseases.
Format
- Hardback
License
© 2021 by the authors; CC BY-NC-ND license
Keywords
mTOR; histone deacetylase; prostate cancer; integrins; adhesion; invasion; cell metabolism; T cells; Foxp3; mTOR; Acute Lymphoblastic leukemia; targeted therapy; mTOR; metabolism; cell signalling; mTOR signalling; metabolism; head and neck cancer; mutant genes; biomarkers; targeted therapies; clinical trials; cancers; mTOR; inhibitors; photodynamic therapy; PI3K; Akt; mTOR; skin cancers; phytochemicals; melanoma; basal cell carcinoma; squamous cell carcinoma; Merkel cell carcinoma; targeted therapy; TNBC; eribulin; PI3K/AKT/mTOR; everolimus; combination; synergy; mTOR signaling; metabolism; tissue regeneration; neuron; muscle; liver; intestine; mTOR; hematologic malignancies; cell metabolism; mTOR; PI3K; Akt; tissue regeneration; regulatory T cells; tumor; photodynamic therapy