**5. Conclusions**

Activation of antibiotics' biosynthesis in actinomycetes by using small-molecule elicitors seems to be a useful technique for drug discovery. The approach allows identification of new metabolite scaffolds and enhances synthesis of low yield secondary metabolites. Moreover, antibiotic-antibiotic induction relationships are believed to be the basis of chemical signaling between different actinobacterial strains and are, therefore, of interest for chemical ecology. Elicitation is an obvious cost-effective approach in biotechnology for increasing antibiotic yields and reducing fermentation time.

**Acknowledgments:** This work was supported in part by RFBR (project No. 18-33-00044) and by the budget funding of the topic 006 "Isolation and physico-phemical characterization of microbially produced antibiotic compounds" at the Gause Institute of New Antibiotics.

**Conflicts of Interest:** The authors declare no conflict of interest.
