**5. Conclusions**

The integration of enzyme activity, kinetics, and in silico docking studies provided principle insights into the molecular basis underlying ligand binding affinity and BACE1 and AChE inhibition. Accordingly, these results suggested that phlorotannins from *E. cava*, especially 8,8-bieckol, have noteworthy potential for the possible development as treatments and/or preventative agents against AD.

**Author Contributions:** Data curation, writing-original draft, J.L.; Supervision, review and editing, M.J.

**Funding:** This research was funded by Dong-A University.

**Conflicts of Interest:** All authors have no conflict of interest to declare.
