*Review* **A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors**

**Te Li 1, Ning Wang 2, Ting Zhang 1, Bin Zhang 1,\*, Thavarool P. Sajeevan 3, Valsamma Joseph 3, Lorene Armstrong 4, Shan He 1, Xiaojun Yan 1 and C. Benjamin Naman 1,5,\***


Received: 25 July 2019; Accepted: 18 August 2019; Published: 23 August 2019

**Abstract:** Protein kinases are validated drug targets for a number of therapeutic areas, as kinase deregulation is known to play an essential role in many disease states. Many investigated protein kinase inhibitors are natural product small molecules or their derivatives. Many marine-derived natural products from various marine sources, such as bacteria and cyanobacteria, fungi, animals, algae, soft corals, sponges, etc. have been found to have potent kinase inhibitory activity, or desirable pharmacophores for further development. This review covers the new compounds reported from the beginning of 2014 through the middle of 2019 as having been isolated from marine organisms and having potential therapeutic applications due to kinase inhibitory and associated bioactivities. Moreover, some existing clinical drugs based on marine-derived natural product scaffolds are also discussed.

**Keywords:** kinase inhibitors; drug development; marine natural products
