*2.7. Statistical Analysis*

Statistical analysis was performed on the data collected from swelling, stability, and payload release tests. All tests were performed in triplicate and results have been reported as mean ± standard deviation. Comparison among results was performed through GraphPad Prism (GraphPad Software, Inc., La Jolla, CA, USA, version 5.03, 2009; http://www.graphpad.com) using a Two-way ANOVA analysis followed by Bo fferoni's multiple comparison tests. The degree of statistical di fference among the results was defined in accordance to Bo ffito et al. [21].

## **3. Results and Discussion**

## *3.1. Cu-MBGs Loaded with Ibu*
