**4. Conclusions**

In this work, we investigated a SiC-coated nanofluidic membrane capable of the reproducible control of analyte transport via electrostatic gating. The application of a low-intensity electrical potential to the gate electrode allowed us to alter nanochannel surface charge, leading to tunable membrane charge-selectivity, and control over the release of methotrexate and quantum dots. Electrochemical characterization showed that SiC dielectric coating exhibited low leakage current and reduced intrinsic charge as compared to SiO2. Moreover, SiC offered chemical bioinertness, which rendered it an ideal candidate for use in biomedical devices for therapeutic delivery based on electrostatic-gating. In this context, our membranes could be employed as actuators for remotely controlled drug delivery systems. The low voltage needed to modulate the release rate could be provided via small scale and low-power circuitry. This investigation might pave the way for the development of the next generation of drug delivery systems, enabling pre-programmed or remotely managed pharmaceutic administration. Further, our gated nanofluidic membrane might find applicability in molecular sieving and lab on a chip diagnostic.
