**Table 1.** *Cont.*

Abbreviations: bFGF: basic fibroblast growth factor; BMP-2: bone morphogenetic protein 2; bMSCs: murine bone mesenchymal stem cells; CA: carbonic anhydrase; CpG@OVA: ovalbumin-loaded cytosine–phosphate–guanine (CpG) oligodeoxynucleotide; DMOHS: dendritic mesoporous organosilica hollow spheres; EspA: an immunogenic protein from enterohaemorrhagic *Escherichia Coli*; GM-CSF: murine granulocyte-macrophage colony-stimulating factor; GPx: glutathione peroxidase; HMSNs: hollow mesoporous silica nanoparticles; HRP: horseradish peroxidase; IgG: immunoglobulin G; IL-2: interleukin-2; ORF2: open reading frame from porcine circovirus type 2; OVA: chicken ovalbumin; RSNs: rough (non-porous and core–shell) silica nanoparticles; SOD: superoxide dismutase; SPIONs: superparamagnetic iron oxide nanoparticles.

**Figure 3.** Roles and examples of typical therapeutic proteins delivered with silica-based nanosystems.
