*Review* **MEATabolomics: Muscle and Meat Metabolomics in Domestic Animals**

#### **Susumu Muroya 1,\*, Shuji Ueda 2, Tomohiko Komatsu 3, Takuya Miyakawa 4 and Per Ertbjerg 5**


Received: 26 March 2020; Accepted: 7 May 2020; Published: 11 May 2020

**Abstract:** In the past decades, metabolomics has been used to comprehensively understand a variety of food materials for improvement and assessment of food quality. Farm animal skeletal muscles and meat are one of the major targets of metabolomics for the characterization of meat and the exploration of biomarkers in the production system. For identification of potential biomarkers to control meat quality, studies of animal muscles and meat with metabolomics (MEATabolomics) has been conducted in combination with analyses of meat quality traits, focusing on specific factors associated with animal genetic background and sensory scores, or conditions in feeding system and treatments of meat in the processes such as postmortem storage, processing, and hygiene control. Currently, most of MEATabolomics approaches combine separation techniques (gas or liquid chromatography, and capillary electrophoresis)–mass spectrometry (MS) or nuclear magnetic resonance (NMR) approaches with the downstream multivariate analyses, depending on the polarity and/or hydrophobicity of the targeted metabolites. Studies employing these approaches provide useful information to monitor meat quality traits e fficiently and to understand the genetic background and production system of animals behind the meat quality. MEATabolomics is expected to improve the knowledge and methodologies in animal breeding and feeding, meat storage and processing, and prediction of meat quality.

**Keywords:** authentication; biomarker; breed; feeding; meat quality traits; metabolite; postmortem aging; processing; skeletal muscle
