*3.5. Pain: Not Perceived*

As previously stated in this study both patients with simple hyperkeratotic lesions and patients with leucoplakia were included. In order to highlight if the treatment has a different efficacy between the two lesions, the patients were divided into two groups taking into consideration the nature of the lesions. For each group we analysed the same parameters used in the previous paragraphs and then we compared the results. Regarding discomfort, tactile perception and pain there are not substantial differences neither between the two groups nor between the groups and the general trend previously described. The only difference is in the variation of the size: leucoplakia follows the general trend, in fact the size reduced by 17% between T0 and T1, between T1 and T2 the size reduced by 63%, between T2 and T3 a variation of 39% occurred and finally between T3 and T4 there was a variation of 36%; in all cases the results were statistically significant. With regard to patients with hyperkeratosis, the dimensional variation shows a constant reduction during all the observations, the data showed: between T0 and T1 there was a reduction of 20%, between T1 and T2 the dimension varied by 28% and continued to do so in the following weeks of observation.

**Figure 4.** In this graph can be seen the trend of tactile perception perceived throughout the treatment. The data were divided as follow: perception felt before the patient was subjected to treatment, right after the irradiation of the lesion and in the days following the session. The data refer to the entire month of observation.
