*3.4. Oral Capsules Administration: An Improvement for Fecal Microbiota Transplantation Safety*

The oral capsule administration form has proven an equal effectiveness [66] and will prevent the adverse event due to the conventional colonoscopy-delivered upper and lower gastrointestinal routes of FMT, especially bowel perforation over-sedation, aspiration, bleeding, and splenic laceration [67,68]. Some studies reported patient deaths due to the underlying disease, where the patient has not responded to the FMT. Our clinical experience and our 5 years collaboration with patients' associations has also shown to us that an important rate of the patients and their relatives are waiting for innovating treatments targeting new pathways, with a better tolerance than antipsychotics. In France, the microbiota hypothesis is very popular and highly broadcasted in the media.
