**5. Conclusions**

This systematic review shows that any type of physical activity, lasting 20 to 60 min and performed two to five times per week for six to 18 weeks, may be effective in reducing the risk of burn-out. The few observational studies linking sedentary and dietary behavior with burn-out risk suggest that engaging in frequent sedentary behavior and eating less healthy are each associated with higher burn-out risk. More high-quality research is needed to unravel the causal relationship between sedentary and dietary behavior and the risk of burn-out.

**Author Contributions:** This work was carried out in collaboration between the authors Y.V., K.D.M., E.V.D.L., E.V.H., E.Z. and T.D. Y.V., K.D.M., E.V.H., E.Z. and T.D. designed the study. Y.V. performed the literature search, data extraction, data-analysis and drafted the manuscript. E.V.D.L. conducted the literature search and participated in the data extraction and data-analysis. K.D.M., E.V.H., E.Z. and T.D. provided guidance about the content of the review and contributed to multiple revisions of the manuscript. All authors read and approved the final manuscript.

**Funding:** This research received no external funding.

**Acknowledgments:** We thank Katrien Alewaeters, the head of the university library, for reviewing the methodology of the search and selection process of this systematic review.

**Conflicts of Interest:** The authors declare that they have no conflict of interests.
