*2.1. Subjects*

The population sample was obtained from the main state-wide MS associations who were previously informed on the characteristics of the study. Sixty-seven people were interested in voluntarily taking part in the study. The following selection criteria were applied: patients over 18 years of age diagnosed with MS at least 6 months prior and treated with glatiramer acetate and interferon beta. On the other hand, the exclusion criteria included: pregnant or breastfeeding women, patients with tracheotomy, stoma or with short bowel syndrome, patients with dementia, evidence of alcohol or drug abuse, with myocardial infarction, heart failure, cardia dysrhythmia, symptoms of angina or other heart conditions, patients with kidney conditions with creatinine levels two times higher than normal markers, patients with elevated liver markers three times higher than normal or with chronic liver disease, patients with metabolic or endocrine diseases such as hyperthyroidism or diabetes, patients with acromegaly, patients with polycystic ovary syndrome or MS patients who were included in other researches with experimental drugs or treatment.
