**5. Conclusions**

Diabetes mellitus is a severe metabolic chronic disease that is most prevalent in developed countries. The general immunocompromised state with an often-poor glucose control often leads to secondary diseases in DM individuals. The biofilm fungal infections in diabetic patients are recognized to be more complicated to treat than they are in healthy patients, especially if related to medical devices. Among the candidiasis, oral diseases are the most frequent infections that occur in DM patients, as well

as VVC and, more seriously, systemic candidiasis. The reports of these cases and the results of the elected therapeutic are extremely important if we are to continue to treat these patients in the most effective manner.

**Author Contributions:** C.F.R. and M.E.R. made the literature review and analyzed the data; C.F.R., M.E.R., and M.H. wrote the paper.

**Funding:** This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of: the strategic funding of UID/BIO/04469/2013 unit, COMPETE 2020 (POCI-01-0145-FEDER-006684) and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020-Programa Operacional Regional do Norte, financially supported by project UID/EQU/00511/2019 - Laboratory for Process Engineering, Environment, Biotechnology and Energy – LEPABE funded by national funds through FCT/MCTES (PIDDAC), and by Célia F. Rodrigues' [SFRH/BD/93078/2013] PhD gran<sup>t</sup> and M. Elisa Rodrigues [SFRH/BPD/95401/2013] post-doc grant.

**Acknowledgments:** The authors would like to thank Liliana Araújo, from the Imperial College, London, for reviewing the English.

**Conflicts of Interest:** The authors declare no conflict of interest. The founding sponsors had no role in the design of the study, in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results.
