**Management of** *Streptococcus mutans***-***Candida* **spp. Oral Biofilms' Infections: Paving the Way for E** ff**ective Clinical Interventions**

#### **Bahare Salehi 1, Dorota Kregiel 2, Gail Mahady 3, Javad Sharifi-Rad 4,5,\*, Natália Martins 6,7,\* and Célia F. Rodrigues 8,\***


Received: 6 January 2020; Accepted: 12 February 2020; Published: 14 February 2020

**Abstract:** Oral diseases are considered the most common noncommunicable diseases and are related to serious local and systemic disorders. Oral pathogens can grow and spread in the oral mucosae and frequently in biomaterials (e.g., dentures or prostheses) under polymicrobial biofilms, leading to several disorders such as dental caries and periodontal disease. Biofilms harbor a complex array of interacting microbes, increasingly unapproachable to antimicrobials and with dynamic processes key to disease pathogenicity, which partially explain the gradual loss of response towards conventional therapeutic regimens. New drugs (synthesized and natural) and other therapies that have revealed promising results for the treatment or control of these mixed biofilms are presented and discussed here. A structured search of bibliographic databases was applied to include recent research. There are several promising new approaches in the treatment of *Candida* spp.–*Streptococcus mutans* oral mixed biofilms that could be clinically applied in the near future. These findings confirm the importance of developing e ffective therapies for oral *Candida*–bacterial infections.

**Keywords:** oral biofilm; infection control; *Streptococcus mutans*; *Candida* spp.; natural compounds; antimicrobial resistance
