**5. Conclusions**

By interviewing experts at our partner sites, we identified and consolidated for the first time a list of requirements for IT-supported preparation of molecular tumor boards based on cBioPortal. This list comprises a total of 24 requirements that had not ye<sup>t</sup> been implemented during the time of the interviews. For almost all of them and their subordinated features, we have created descriptive screenshot mockups (54 in total) which supported the interview process and may contribute to the further development of cBioPortal. This work provides important information based on the clinical needs that will ultimately support the members of an MTB interpret the complex data for a personalized therapy recommendation.

#### **Supplementary Materials:** Supplementary materials can be found at http://www.mdpi.com/2075-4418/10/2/93/s1.

**Author Contributions:** Conceptualization, P.B., M.H., P.U., M.B. (Melanie Boerries) and J.C.; data curation, P.B. and M.H.; formal analysis, P.B. and M.H.; investigation, P.B., M.H., M.B. (Melanie Boerries) and J.C.; methodology, P.B., M.H. and J.C.; project administration, P.B., M.H. and J.C.; supervision, M.B. (Melanie Boerries) and J.C.; Validation, P.B., M.H., P.U., M.B. (Melanie Boerries) and J.C.; visualization, P.B.; writing—original draft, P.B.; writing—review and editing, P.B., M.H., P.U., P.M., M.B. (Martin Boeker), T.A., F.H., E.M., D.N., C.P., D.S., N.v.B., S.W., H.B., M.B. (Melanie Boerries) and J.C. All authors have read and agreed to the published version of the manuscript.

**Funding:** This research is supported by MIRACUM that is funded by the German Federal Ministry of Education and Research (BMBF) within the "Medical Informatics Funding Scheme" (FKZ 01ZZ1801A and FKZ 01ZZ1801B).

**Acknowledgments:** We especially thank all interview participants for their willingness and time to conduct the interviews. In addition, we would like to thank Nikolaus Schultz and Jianjiong Gao from the Memorial Sloan Kettering Cancer Center (MSKCC), who provided us with their feedback on the identified requirements and our planned changes to cBioPortal. The present work was performed in (partial) fulfillment of the requirements for obtaining the degree "Dr. med." from the Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) (Philipp Buechner).

**Conflicts of Interest:** The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
