*3.6. Relationship between LA Strain Change and Baseline Age and Male Gender*

The % mean change of LA strain was not related to baseline mean age or male gender (β = −0.20 (from 0.159 to <sup>−</sup>0.516), *<sup>p</sup>* <sup>=</sup> 0.20, Tau <sup>=</sup> 0.00%, I<sup>2</sup> <sup>=</sup> 0.00%, Q <sup>=</sup> 0.19, d <sup>=</sup> 4) or age(<sup>β</sup> <sup>=</sup> <sup>−</sup>0.24 (from 0.22 to <sup>−</sup>0.69), *p* = 0.27, Tau = 0.00% I<sup>2</sup> = 0.00%, Q = 1.20, d = 4) (Figure S5: Supplement 7). There was no heterogeneity across the included studies.
