3.9.2. Pridopidine

Pridopidine is a modulator of the dopamine 2 receptor [130] and activates the sigma-1 receptor [131]. In the most recent trials of pridopidine, no improvement in motor symptoms (unified Huntington's Disease rating scale - total motor score (UHDRS-TMS)) was observed with placebo [132–134]. High level of pridopidine is found in brain-derived neurotrophic factor (BDNF) and diminishes mHTT aggregate size and improved motor performance in R6/2 mice [135,136]. In an early-stage HD, improvement in the total motor score (TMS) was observed in treated patients [136,137].
