**5. Conclusions**

Patients with JOHD seem to have elevated rHR compared to healthy controls. Additionally, the JOHD participants had significantly decreased SBP compared to the healthy controls. These changes seem to be indicative of progressive neurodegeneration and may further advance our understanding of the neurobiology of JOHD.

**Author Contributions:** Conceptualization, J.L.S. and P.C.N.; methodology, J.L.S. and P.C.N.; software, J.L.S.; validation, J.L.S. and P.C.N.; formal analysis, J.L.S.; investigation, J.L.S. and P.C.N.; resources, P.C.N.; data curation, P.C.N.; writing—original draft preparation, J.L.S.; writing—review and editing P.C.N.; visualization, J.L.S.; supervision, P.C.N.; project administration, P.C.N.; funding acquisition P.C.N. All authors have read and agreed to the published version of the manuscript.

**Funding:** This study was supported by National Institute of Neurological Disorders and Stroke (NINDS; R01NS055903). The APC was funded by National Institute of Neurological Disorders and Stroke (NINDS; R01NS055903).

**Acknowledgments:** We thank all of the co-investigators of the Kids-HD and Kids-JOHD study, as well as the participants and their families.

**Conflicts of Interest:** The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
