3.9.3. Triheptanoin

Triheptanoin is a triglyceride that reverses the metabolic defects in HD by supplying substrates to the Krebs cycle [138]. Recently, a phase II study using triheptanoin was conducted in the early phase of HD patients (listed at clincialtrials.gov under #NCT02453061).

#### 3.9.4. Latrepirdine (Dimebon)

Latrepirdine stabilize and enhance mitochondrial membranes and functions. In a short duration trial, latrepirdine promoted cognitive improvement (MMSE) in mild to moderate HD patients [11,139]. At the time of writing this, a total of 13 clinical trials using latrepirdine have been reported on clinicaltrials. gov (NCT00497159, NCT01085266, NCT00920946, NCT00387270, NCT00988624, NCT00827034, NCT00990613, NCT00824590, NCT00931073, NCT00831506, NCT00788047, NCT00825084).
