3.8.7. Diet

Various studies indicate that a Mediterranean-type diet may delay the onset of other neurodegenerative diseases, like AD, PD, dementia and cognitive impairment [125]. Recently a study highlighted that a Mediterranean-type diet a ffects the time to HD phenoconversion. In fact, eating high amounts of dairy products was associated with an increased risk of phenoconversion. This may be due to a lower level of urate, which leads to a faster progression and manifestation of HD. These types of diet-related studies need further investigation [84,107,126]. Intermittent fasting promotes autophagy and cleared the mHTT [127].

#### *3.9. Some Promising Clinical Trials*

#### 3.9.1. Cysteamine (CYST)

Cysteamine controls oxidation levels through increasing concentration of glutathione, activation of protein catabolism through the hindrance of transglutaminase and induction of heat shock proteins (HSPs) e ffects [128]. Inhibition of transglutaminase is the putative mode of action and is observed in R6/2 and zQ175 mouse models of HD [129]. The Cysteamine-HD phase II/III trials indicated a delay in the release of cysteamine in HD patients.
