3.8.4. BN82451

BN82451 inhibits cyclooxygenases and provides antioxidant, anti-inflammatory and neuroprotective e ffects [80]. It also improved motor function and survival, decreased brain atrophy, neuronal atrophy, and neuronal mHTT inclusions in the R6/2 mice [81]. Recently, a phase II clinical

trial has been completed in male HD patients. As per clinicaltrials.gov (NCT02231580), no results have been published.

#### 3.8.5. Antipsychotic Drugs

Antipsychotic drugs are used to treat chorea associated symptoms because they block or modulate dopamine receptors. Many antipsychotic drugs (especially typical antipsychotics) produce motor dysfunction resembling Parkinson's disease (PD). Currently, a phase III trial comparing TBZ with olanzapine and tiapridal is under evaluation [39].

#### 3.8.6. Antiapoptotic Drugs

Caspase cleavage (mainly caspase-3 and -6) occur in mHTT [83]. Mutating the caspase cleavage sites on mHTT leads to neuroprotection and prevents neurodegeneration in yeas<sup>t</sup> artificial chromosome (YAC) mice that express mHTT. Caspase-3 and -6 resistant mice did not develop HD neurodegeneration, indicating that cleavage at these caspase sites plays an important role in neurodegeneration of HD [82,123,124].
