**5. Conclusions**

In summary, beside from early abnormalities in behavior due to HD pathology, children seem to have higher socio-medical problems related to additional burden caused by early affected parents and instable family backgrounds.

**Author Contributions:** J.A.: Conception, Organization, Execution, Design, Writing of the first draft; C.T.: Conception, Organization, Execution, Design; T.L.: Conception, Review and Critique; C.S.: Conception, Organization, Design, Review and Critique. All authors have read and agreed to the published version of the manuscript.

**Acknowledgments:** We acknowledge support by the DFG Open Access Publication Funds of the Ruhr-Universität Bochum.

**Conflicts of Interest:** Saft reports personal fees/honoraria from Teva Pharma GmbH, as well as non-financial support and other support from ENROLL-HD study (CHDI), PRIDE-HD (TEVA), LEGATO (TEVA), and Amaryllis (Pfizer), ASO (IONIS Pharmaceuticals and Roche AG) for the conducting of studies and grants from Biogen all outside the submitted work and without relevance to the manuscript. The other authors declare they have no conflict of interest concerning the research related to this manuscript.
