*Communication* **Autonomic Changes in Juvenile-Onset Huntington's Disease**

#### **Jordan L. Schultz 1,2,\* and Peg C. Nopoulos 1,2,3**


Received: 24 July 2020; Accepted: 24 August 2020; Published: 26 August 2020

**Abstract:** Patients with adult-onset Huntington's Disease (AOHD) have been found to have dysfunction of the autonomic nervous system that is thought to be secondary to neurodegeneration causing dysfunction of the brain–heart axis. However, this relationship has not been investigated in patients with juvenile-onset HD (JOHD). The aim of this study was to compare simple physiologic measures between patients with JOHD (*n* = 27 participants with 64 visits) and participants without the gene expansion that causes HD (GNE group; *n* = 259 participants with 395 visits). Using data from the Kids-JOHD study, we compared mean resting heart rate (rHR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) between the JOHD and GNE groups. We also divided the JOHD group into those with childhood-onset JOHD (motor diagnosis received before the age of 13, [*n* = 16]) and those with adolescent-onset JOHD (motor diagnosis received at or after the age of 13 [*n* = 11]). We used linear mixed-e ffects models to compare the group means while controlling for age, sex, and parental socioeconomic status and including a random e ffect per participant and family. For the primary analysis, we found that the JOHD group had significant increases in their rHR compared to the GNE group. Conversely, the JOHD group had significantly lower SBP compared to the GNE group. The JOHD group also had lower DBP compared to the GNE group, but the results did not reach significance. SBP and DBP decreased as disease duration of JOHD increased, but rHR did not continue to increase. Resting heart rate is more sensitive to changes in autonomic function as compared to SBP. Therefore, these results seem to indicate that early neurodegenerative changes of the central autonomic network likely lead to an increase in rHR while later progression of JOHD leads to changes in blood pressure. We hypothesize that these later changes in blood pressure are secondary to neurodegeneration in brainstem regions such as the medulla.

**Keywords:** juvenile-onset Huntington's Disease; autonomic; neurodegeneration
