*2.4. Preparation of Drug-CD-Sepiolite (SV) Ternary Systems*

Ternary physical mixtures (PM) were prepared by 15 min tumble mixing the drug with the selected CD (HCT:RAMEB 1:1 mol/mol) and SV (HCT:SV 1:4 *w*/*w* ratio). Co-evaporated ternary products (COE) were prepared by dissolving equimolar amounts of HCT and RAMEB in the minimum amount of ethanol and water, respectively, mixing the solutions, suspending SV (HCT:SV 1:4 *w*/*w* ratio) under mixing and removing the solvent by rotary evaporation; the solid product was collected and left to dry in an oven for 24 h at 40 ◦C.
