2.2.4. BioMarkers of EndMT

In a recent study biomarkers of partial microvasculature EndMT (Fascin and Vimentin) and of tubular EMT (Vimentin) were analyzed with immunoistochemistry in renal biopsies performed in early post-transplant due to DGF, showing ATN lesions. Extent of ATN was correlated with short and long-term (2 year) graft dysfunction only in the presence of partial EndMT (pEndMT) biomarkers expression, suggesting that early endothelial cell activation can identify patients at risk of incomplete recovery after DGF [28]. EndMt will be discussed in detail in the following Section 4.1.3 concerning mechanisms of chronic rejection and IFTA.
