2.3.10. Other Studies Concerning Changes in uL-FABP

Hiraki showed that after a single case of a 20-min moderate intensity exercise (20-min treadmill walking, 40–60% exercise intensity) session in 31 adults with chronic kidney disease (CKD), there was no change in uL-FABP. This exercise was rather gentle and even albuminuria was not increased [55]. Kosaki studied individuals aged 50–83 without CKD and found that uL-FABP was the lowest in participants with a higher level of aerobic fitness and muscular strength [56,57] and that 12-week aerobic exercise training significantly decreases uL-FABP levels [57]. Relative changes in uFABP were significantly correlated with the relative changes in physical activity and the mean arterial pressure after intervention. The authors concluded that "habitual exercise appears to be associated with the degree of several stresses on the proximal tubule and to be beneficial for kidney health in middle-aged and older adults" [57]. Uchiyama et al. found a decrease in uL-FABP after a 12-week, home-based exercise program involving 47 patients undergoing peritoneal dialysis [58].
