*3.4. Other Potential Urinary Biomarkers*

Other urinary molecules have been proposed as markers of AR.

High urinary π-GST values at postoperative day 1 discriminated AR (sensitivity, 100%; specificity, 66.6%) as well as between DGF from normal-functioning grafts (sensitivity, 100%; specificity, 62.6%). Similarly, α-GST values > 33.97 ng/mg uCrea identified AR, with a lower sensitivity (77.7%) but optimal specificity (100%) [105].

Urinary untargeted metabolomic profiling led to identification of a panel of five potential biomarkers (guanidoacetil acid, methylimidazolacetic acid, dopamine, 4-guanidobutyric acid, and L-tryptophan), which discriminated between TCMR and stable graft (ROC curve AUC: sensitivity 90%; specificity 84.6%) [106].
