*3.5. Extraction and isolation of moraxanthin* (**1**)

The algal pellet (4 g) was extracted once with MeOH (40 mL). The extract was dried to give a dark green oil (104 mg) which was subjected to reversed-phase HPLC separation on a Varian Prostar 210 apparatus equipped with an Varian 325 UV detector [column: RP-18, 10 *ΐ*m, 250 × 10 mm; eluent: MeOH/H2O (9:1), flow 5 mL/min, UV detector set at 430 nm] to give partially purified moraxanthin (3.4 mg). Further reversed phase HPLC [column: RP-18, 3 *ΐ*m, 250 × 4.6 mm; eluent: MeOH/H2O (8:2), flow 1 mL/min, UV detector set at 430 nm] gave pure moraxanthin **1** (1.1 mg), whose identity was confirmed by HPLC analysis as described in Section 4.3. 

## *3.6. Moraxanthin* (**1**)

Dark yellow oil; CD (MeOH; *c* 3.06ȉ10–6 M): ̇Ή471 +9.9, ̇Ή446 +11.9, ̇Ή422 +9.0; UV (EtOH): *Ώ*max nm (*Ή*): 421 (89000), 444 (129000), 472 (118000); ESI MS *m*/*z* 779 [M + Na]+; HRESIMS *m*/*z* 779.4879 [M + Na]+ (calcd. for C48 H68NaO7, 779.4857). For 1H and 13C NMR spectroscopic data, see Table 2. 
