**Acknowledgments**

We appreciate Shiro Ono and Hiromi Okuyama (Osaka Ohtani University) for their help in the measurement of the serum levels of cytokines. This work was supported by the Program to Disseminate the Tenure Tracking System of the Ministry of Education, Culture, Sports, Science and Technology, the Japanese Government, and by the Adaptable and Seamless Technology Transfer Program through target-driven R & D, Japan Science and Technology Agency (AS242Z03463Q). 
