*2.11. Statistical Analysis*

GraphPad Prism v.5.0a software (GraphPad Software, San Diego, CA, USA) was used to analyze the data, prepare the graphs and perform all statistical analysis. All experimental results (quantitative RT-qPCR analysis, MTT assays, titration assays, luciferase activity assays, and quantitative fluorescence intensity analysis) were displayed in the graphs as the mean ± standard deviation (S.D.). The normal distribution of data was confirmed using Kolmogorov-Smirnov test in experiments with sample sizes n ≥ 6. Experiments where normality test could not be performed because of sample size limitations (n = 3) normal distribution of the data was assumed. The differences among means between multiple (more than two) groups were analyzed by One-way ANOVA or Two-way ANOVA followed by Dunnett's or Bonferroni's Multiple Comparison Test as indicated in each figure legend. One-way ANOVA was used for single variable analysis in Figures 1D,E, 2, 3D and 4–9, while Two-way ANOVA was used in kinetic experiments for two variable analysis in Figures 1A,C and 3B. The statistical significance was set as: \* *p* < 0.05; \*\* *p* < 0.01; \*\*\* *p* < 0.001.
