*2.9. Statistical Analyses*

Statistical analyses of qRT-PCR and luciferase assay results were performed using the Prism v7 or v8 software (GraphPad Software, San Diego, CA, USA) using the tests indicated in the figure legends. Statistical significance was evaluated using the following *p* values: *p* < 0.05 (\*), *p* < 0.01 (\*\*), *p* < 0.001 (\*\*\*) or *p* < 0.0001 (\*\*\*\*). Di fferences with a *p*-value < 0.05 were considered significant. Statistical analysis of the RNASeq data is described in the Bioinformatics analysis section above.

### *2.10. Data and Software Availability*

The entire set of RNAseq data has been submitted to the Gene Expression Omnibus (GEO) database (http://www.ncbi.nlm.nih.gov/geo) under accession number GEO: GSE111195.
