*2.2. siRNA Transfection*

The sequences of non-targeting control (Ctrl) and STAT2- and IRF9-directed RNAi oligonucleotides (Dharmacon, Lafayette, CO, USA) have previously been described in [14]. U3A cells at 30% confluency were transfected using the Oligofectamine transfection reagen<sup>t</sup> (Life Technologies-Thermofisher, Carlsbad, CA, USA). RNAi transfection was pursued for 48 h before stimulation.
