*4.4. HIV*

The presence of PS in the membrane of HIV particles was shown to be an important cofactor for infection and blocking of PS led to a decrease in infection [64,65]. In addition, HIV infection was

inhibited by the addition of lipid vesicles composed of PS that competed with the HIV particles for plasma membrane association, while lipid vesicles containing PC had no effect [64]. Therefore, the binding of CPXV012 peptide to PS in the viral envelope could explain the inhibitory effect observed in the EASY-HIT assay.
