**5. Conclusions**

Our study reveals an imbalance between prooxidants and antioxidants in patients with warts. Moreover, we postulate that sRAGE may represent a potential biomarker of oxidative stress in patients with warts. sRAGE acts as a decoy for AGEs, blocking AGEs-RAGE axis and prevent the augmentation of the oxidative processes. The modulation of sRAGE could be a therapeutic alternative or at least an adjuvant treatment in near future.

**Author Contributions:** All authors have equally contributed to this paper. Conceptualization, C.I.M., I.N., M.T. and M.I.M.; data curation, C.C., M.I.S. and A.C.I.; formal analysis, M.I.S. and C.M.; funding acquisition, C.C.; investigation, C.D.E., C.M. and A.C.I.; methodology, C.I.M., I.N. and M.I.M.; project administration, S.R.G. and M.I.P.; resources, C.C.; software, M.T. and C.D.E.; supervision, S.R.G. and M.I.P.; validation, M.I.S., C.D.E. and C.M.; visualization, A.C.I. and S.R.G.; writing—original draft, C.I.M., I.N. and M.I.M.; writing—review and editing, M.T. and M.I.P.

**Funding:** This research and APC were funded by a gran<sup>t</sup> of Romanian Ministry of Research and Innovation, CCCDI-UEFISCDI, [project number 61PCCDI⁄2018 PN-III-P1-1.2-PCCDI-2017-0341], within PNCDI-III.

**Conflicts of Interest:** The authors declare no conflict of interest.
